B cell development: transcriptional regulation and immunological mechanisms in homeostasis
B lymphocytes are essential elements of the adaptive immune response, performing critical functions such as antigen presentation, cytokine secretion, and antibody production. Their development follows a tightly regulated progression from hematopoietic stem cells to differentiated plasma or memory ce...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593338/full |
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| author | Jorge Gómez-Manríquez Jorge Hernández-Bello José Francisco Muñoz-Valle Sonia Sifuentes-Franco Omar Graciano-Machuca José Javier Morales-Núñez José Javier Morales-Núñez |
| author_facet | Jorge Gómez-Manríquez Jorge Hernández-Bello José Francisco Muñoz-Valle Sonia Sifuentes-Franco Omar Graciano-Machuca José Javier Morales-Núñez José Javier Morales-Núñez |
| author_sort | Jorge Gómez-Manríquez |
| collection | DOAJ |
| description | B lymphocytes are essential elements of the adaptive immune response, performing critical functions such as antigen presentation, cytokine secretion, and antibody production. Their development follows a tightly regulated progression from hematopoietic stem cells to differentiated plasma or memory cells, orchestraeted by key transcriptional factors including PU.1, Ikaros, E2A, Pax-5, and BCL6. These factors govern gene expression essential for processes such as V(D)J recombination, somatic hypermutation, and immunoglobulin class switching—ensuring proper lineage commitment and the maintenance of immunological tolerance. Dysregulation of these pathways, whether through genetic or epigenetic alterations or chronic inflammatory stimuli, can result in autoimmunity, persistent inflammation, or B cell malignancies. This review provides a comprehensive analysis of the transcriptional and immunological mechanisms underlying B cell development and homeostasis, emphasizing their roles in disease pathophysiology and potential as therapeutic targets. |
| format | Article |
| id | doaj-art-276ecc4074584c72bc1ad11a01cd6bf2 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-276ecc4074584c72bc1ad11a01cd6bf22025-08-20T02:55:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-08-011610.3389/fimmu.2025.15933381593338B cell development: transcriptional regulation and immunological mechanisms in homeostasisJorge Gómez-Manríquez0Jorge Hernández-Bello1José Francisco Muñoz-Valle2Sonia Sifuentes-Franco3Omar Graciano-Machuca4José Javier Morales-Núñez5José Javier Morales-Núñez6Programa Educativo Médico Cirujano y Partero, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, Jalisco, MexicoInstituto de Investigación en Ciencias Biomédicas (IICB), Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, MexicoInstituto de Investigación en Ciencias Biomédicas (IICB), Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, MexicoLaboratorio de Ciencias Clínicas, Departamento de Ciencias de la Salud, Centro Universitario de los Valles, Universidad de Guadalajara, Ameca, Jalisco, MexicoLaboratorio de Ciencias Clínicas, Departamento de Ciencias de la Salud, Centro Universitario de los Valles, Universidad de Guadalajara, Ameca, Jalisco, MexicoLaboratorio de Ciencias Clínicas, Departamento de Ciencias de la Salud, Centro Universitario de los Valles, Universidad de Guadalajara, Ameca, Jalisco, MexicoDepartamento de Morfología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, MexicoB lymphocytes are essential elements of the adaptive immune response, performing critical functions such as antigen presentation, cytokine secretion, and antibody production. Their development follows a tightly regulated progression from hematopoietic stem cells to differentiated plasma or memory cells, orchestraeted by key transcriptional factors including PU.1, Ikaros, E2A, Pax-5, and BCL6. These factors govern gene expression essential for processes such as V(D)J recombination, somatic hypermutation, and immunoglobulin class switching—ensuring proper lineage commitment and the maintenance of immunological tolerance. Dysregulation of these pathways, whether through genetic or epigenetic alterations or chronic inflammatory stimuli, can result in autoimmunity, persistent inflammation, or B cell malignancies. This review provides a comprehensive analysis of the transcriptional and immunological mechanisms underlying B cell development and homeostasis, emphasizing their roles in disease pathophysiology and potential as therapeutic targets.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593338/fullB lymphocyteB cell receptortranscriptional factorstoleranceimmunoglobulins |
| spellingShingle | Jorge Gómez-Manríquez Jorge Hernández-Bello José Francisco Muñoz-Valle Sonia Sifuentes-Franco Omar Graciano-Machuca José Javier Morales-Núñez José Javier Morales-Núñez B cell development: transcriptional regulation and immunological mechanisms in homeostasis Frontiers in Immunology B lymphocyte B cell receptor transcriptional factors tolerance immunoglobulins |
| title | B cell development: transcriptional regulation and immunological mechanisms in homeostasis |
| title_full | B cell development: transcriptional regulation and immunological mechanisms in homeostasis |
| title_fullStr | B cell development: transcriptional regulation and immunological mechanisms in homeostasis |
| title_full_unstemmed | B cell development: transcriptional regulation and immunological mechanisms in homeostasis |
| title_short | B cell development: transcriptional regulation and immunological mechanisms in homeostasis |
| title_sort | b cell development transcriptional regulation and immunological mechanisms in homeostasis |
| topic | B lymphocyte B cell receptor transcriptional factors tolerance immunoglobulins |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593338/full |
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