Using structural equation model to analyse the effect of psychological pressure on the patients with essential hypertension blood pressure and blood biochemical indicators
Abstract Background Essential hypertension (EH) was the result of the combined action of environmental and genetic factors, and its risk factors were numerous, psychological factors were thought to contribute to the development of EH. Methods We randomized 600 outpatients and inpatients during the y...
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BMC
2025-05-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04795-5 |
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| author | Chaoqun Wu Jiani Zhou Yuan Gao Dongping Cai Jing Lin Miaohui Zhao |
| author_facet | Chaoqun Wu Jiani Zhou Yuan Gao Dongping Cai Jing Lin Miaohui Zhao |
| author_sort | Chaoqun Wu |
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| description | Abstract Background Essential hypertension (EH) was the result of the combined action of environmental and genetic factors, and its risk factors were numerous, psychological factors were thought to contribute to the development of EH. Methods We randomized 600 outpatients and inpatients during the year from January 2018 to December 2021 in the Ningbo Medical Treatment Center Li Huili Hospital. Basic information including blood pressure, blood lipids, AngII, aldosterone and Homocysteine was recorded, and the Chinese Perceived Stress Scale (CPSS) questionnaire was completed. We divided them into four groups: high psychological pressure hypertension group(HPPH), low psychological pressure hypertension group(LPPH), high psychological pressure control group (HPPC) and low psychological pressure control group (LPPC). Using SEM to explore the direct and indirect effects of psychological pressure on blood pressure and biochemical indicators. Result SBP, DBP, TC, TG, LDL-C, Ang II, ALD and Hcy of HPPH were significantly higher than those of LPPH, HPPC and LPPC (p < 0.05). SBP, DBP, TC, TG, LDL-C, Ang II, ALD and Hcy of LPPH were significantly higher than those of HPPC and LPPC. SBP, DBP, TC, TG, LDL-C, Ang II, ALD and Hcy of HPPC were significantly higher than those of LPPC. HDL-C were lowest in HPPH group. Psychological pressure had significantly effect on blood pressure, lipids, AngII, ALD and Hcy(P < 0.05), and it had positive relationship with SBP, DBP, TC, TG, HDL-C, Ang II, ALD, Hcy (P < 0.05), and had negative relationship with HDL-C. AngII and ALD had significantly effects on blood pressure, lipids (P < 0.05), and it had positive relationship with SBP, DBP, TC, TG, ALD(P < 0.05), and had negative relationship with HDL-C(P < 0.05). Blood pressure had significantly effects on Lipids and Hcy (P < 0.05), it had positive relationship with TC, TG, LDL-C (P < 0.05), and had negative relationship with HDL-C(P < 0.05). Conclusion The research demonstrated that psychological pressure plays an important role in the pathophysiological process of essential hypertension and may serve as a potential target for comprehensive hypertension management. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-276b400a55744a6fb864daf4e77a2557 |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-276b400a55744a6fb864daf4e77a25572025-08-20T03:53:08ZengBMCBMC Cardiovascular Disorders1471-22612025-05-012511910.1186/s12872-025-04795-5Using structural equation model to analyse the effect of psychological pressure on the patients with essential hypertension blood pressure and blood biochemical indicatorsChaoqun Wu0Jiani Zhou1Yuan Gao2Dongping Cai3Jing Lin4Miaohui Zhao5Department of General Practice, Ningbo Medical Treatment Center Li Huili HospitalDepartment of General Practice, Ningbo Medical Treatment Center Li Huili HospitalBiliary Pancreatic and Gastrointestinal Surgery, Ningbo No.2 HospitalThe Healthcare Center for Shishan Street of Suzhou New DistrictDepartment of General Practice, Ningbo Medical Treatment Center Li Huili HospitalDepartment of General Practice, Ningbo Medical Treatment Center Li Huili HospitalAbstract Background Essential hypertension (EH) was the result of the combined action of environmental and genetic factors, and its risk factors were numerous, psychological factors were thought to contribute to the development of EH. Methods We randomized 600 outpatients and inpatients during the year from January 2018 to December 2021 in the Ningbo Medical Treatment Center Li Huili Hospital. Basic information including blood pressure, blood lipids, AngII, aldosterone and Homocysteine was recorded, and the Chinese Perceived Stress Scale (CPSS) questionnaire was completed. We divided them into four groups: high psychological pressure hypertension group(HPPH), low psychological pressure hypertension group(LPPH), high psychological pressure control group (HPPC) and low psychological pressure control group (LPPC). Using SEM to explore the direct and indirect effects of psychological pressure on blood pressure and biochemical indicators. Result SBP, DBP, TC, TG, LDL-C, Ang II, ALD and Hcy of HPPH were significantly higher than those of LPPH, HPPC and LPPC (p < 0.05). SBP, DBP, TC, TG, LDL-C, Ang II, ALD and Hcy of LPPH were significantly higher than those of HPPC and LPPC. SBP, DBP, TC, TG, LDL-C, Ang II, ALD and Hcy of HPPC were significantly higher than those of LPPC. HDL-C were lowest in HPPH group. Psychological pressure had significantly effect on blood pressure, lipids, AngII, ALD and Hcy(P < 0.05), and it had positive relationship with SBP, DBP, TC, TG, HDL-C, Ang II, ALD, Hcy (P < 0.05), and had negative relationship with HDL-C. AngII and ALD had significantly effects on blood pressure, lipids (P < 0.05), and it had positive relationship with SBP, DBP, TC, TG, ALD(P < 0.05), and had negative relationship with HDL-C(P < 0.05). Blood pressure had significantly effects on Lipids and Hcy (P < 0.05), it had positive relationship with TC, TG, LDL-C (P < 0.05), and had negative relationship with HDL-C(P < 0.05). Conclusion The research demonstrated that psychological pressure plays an important role in the pathophysiological process of essential hypertension and may serve as a potential target for comprehensive hypertension management. Clinical trial number Not applicable.https://doi.org/10.1186/s12872-025-04795-5Psychological pressureEssential hypertensionBlood lipidAngiotensinIIAldosterone |
| spellingShingle | Chaoqun Wu Jiani Zhou Yuan Gao Dongping Cai Jing Lin Miaohui Zhao Using structural equation model to analyse the effect of psychological pressure on the patients with essential hypertension blood pressure and blood biochemical indicators BMC Cardiovascular Disorders Psychological pressure Essential hypertension Blood lipid AngiotensinII Aldosterone |
| title | Using structural equation model to analyse the effect of psychological pressure on the patients with essential hypertension blood pressure and blood biochemical indicators |
| title_full | Using structural equation model to analyse the effect of psychological pressure on the patients with essential hypertension blood pressure and blood biochemical indicators |
| title_fullStr | Using structural equation model to analyse the effect of psychological pressure on the patients with essential hypertension blood pressure and blood biochemical indicators |
| title_full_unstemmed | Using structural equation model to analyse the effect of psychological pressure on the patients with essential hypertension blood pressure and blood biochemical indicators |
| title_short | Using structural equation model to analyse the effect of psychological pressure on the patients with essential hypertension blood pressure and blood biochemical indicators |
| title_sort | using structural equation model to analyse the effect of psychological pressure on the patients with essential hypertension blood pressure and blood biochemical indicators |
| topic | Psychological pressure Essential hypertension Blood lipid AngiotensinII Aldosterone |
| url | https://doi.org/10.1186/s12872-025-04795-5 |
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