Galectin-3 in solid organ recipients: role in graft pathology and prospects for use
Galectin-3 (Gal-3) is an important regulator of cell adhesion, migration, proliferation, differentiation and apoptosis under pathophysiological conditions. It plays a crucial role in diseases associated with chronic inflammation and fibrosis. In recent years, there have been reports indicating chang...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2023-07-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/1643 |
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| _version_ | 1849242186435002368 |
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| author | D. A. Velikiy M. A. Osoblivaya O. P. Shevchenko |
| author_facet | D. A. Velikiy M. A. Osoblivaya O. P. Shevchenko |
| author_sort | D. A. Velikiy |
| collection | DOAJ |
| description | Galectin-3 (Gal-3) is an important regulator of cell adhesion, migration, proliferation, differentiation and apoptosis under pathophysiological conditions. It plays a crucial role in diseases associated with chronic inflammation and fibrosis. In recent years, there have been reports indicating changes in serum Gal-3 levels in solid organ transplant recipients in the verification of kidney, liver, heart and lung transplant pathologies. Studies on Gal-3 levels and dynamics in solid organ recipients may serve to assess graft conditions using new minimally invasive methods and to identify therapeutic targets for personalized therapy. The first clinical trial data on Gal-3 pharmacological inhibition are emerging. This review summarizes the current understanding of the role of Gal-3 in transplant pathology and the prospects for its use as a diagnostic marker and therapeutic target in solid organ recipients. |
| format | Article |
| id | doaj-art-275d0cb79dcd4c60bdff9ea214a8d124 |
| institution | Kabale University |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2023-07-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-275d0cb79dcd4c60bdff9ea214a8d1242025-08-20T03:59:53ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912023-07-0125212913910.15825/1995-1191-2023-2-129-1391179Galectin-3 in solid organ recipients: role in graft pathology and prospects for useD. A. Velikiy0M. A. Osoblivaya1O. P. Shevchenko2Shumakov National Medical Research Center of Transplantology and Artificial OrgansShumakov National Medical Research Center of Transplantology and Artificial OrgansShumakov National Medical Research Center of Transplantology and Artificial Organs; Sechenov UniversityGalectin-3 (Gal-3) is an important regulator of cell adhesion, migration, proliferation, differentiation and apoptosis under pathophysiological conditions. It plays a crucial role in diseases associated with chronic inflammation and fibrosis. In recent years, there have been reports indicating changes in serum Gal-3 levels in solid organ transplant recipients in the verification of kidney, liver, heart and lung transplant pathologies. Studies on Gal-3 levels and dynamics in solid organ recipients may serve to assess graft conditions using new minimally invasive methods and to identify therapeutic targets for personalized therapy. The first clinical trial data on Gal-3 pharmacological inhibition are emerging. This review summarizes the current understanding of the role of Gal-3 in transplant pathology and the prospects for its use as a diagnostic marker and therapeutic target in solid organ recipients.https://journal.transpl.ru/vtio/article/view/1643galectin3solid organ transplantationgraft pathology |
| spellingShingle | D. A. Velikiy M. A. Osoblivaya O. P. Shevchenko Galectin-3 in solid organ recipients: role in graft pathology and prospects for use Вестник трансплантологии и искусственных органов galectin3 solid organ transplantation graft pathology |
| title | Galectin-3 in solid organ recipients: role in graft pathology and prospects for use |
| title_full | Galectin-3 in solid organ recipients: role in graft pathology and prospects for use |
| title_fullStr | Galectin-3 in solid organ recipients: role in graft pathology and prospects for use |
| title_full_unstemmed | Galectin-3 in solid organ recipients: role in graft pathology and prospects for use |
| title_short | Galectin-3 in solid organ recipients: role in graft pathology and prospects for use |
| title_sort | galectin 3 in solid organ recipients role in graft pathology and prospects for use |
| topic | galectin3 solid organ transplantation graft pathology |
| url | https://journal.transpl.ru/vtio/article/view/1643 |
| work_keys_str_mv | AT davelikiy galectin3insolidorganrecipientsroleingraftpathologyandprospectsforuse AT maosoblivaya galectin3insolidorganrecipientsroleingraftpathologyandprospectsforuse AT opshevchenko galectin3insolidorganrecipientsroleingraftpathologyandprospectsforuse |