In vivo Outcomes of the Application of Stem Cell-derived Conditioned Medium (Secretome) or Its Derivatives toward Skin Flap Following Ischemia–Reperfusion Injury: A Systematic Review of Experimental Studies

In vivo Outcomes of the Application of Stem Cell-derived Conditioned Medium (Secretome) or Its Derivatives toward Skin Flap Following Ischemia–Reperfusion Injury: A Systematic Review of Experimental Studies

Skin flaps are tissue transferred from a donor to a recipient site to fill covering defects in the surface of the body. During transfer, skin flaps are severely predisposed to ischemia not only due to ischemia but also to ischemia–reperfusion (I/R) injury, a paradoxical exacerbation of cellular deat...

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Main Authors: Richard Christian Suteja, I. Gusti Ayu Maha Hiranandini Prawista, I. Komang Hotra Adiputra, Giovanca Verentzia Purnama, Darren Junior, I. Gusti Ngurah Ariestha Satya Diksha, I. Gusti Ngurah Dinda Pratyaksa, I. Dewa Gede Agung Siwa Guptha, Novea Indratmo, Albert Salim, I. Putu Divanaya Suryanov, Gede Wara Samsarga
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-01-01
Series:Turkish Journal of Plastic Surgery
Subjects:
conditioned medium
ischemia–reperfusion injury
regenerative medicine
secretome
skin flap
stem cell
systematic review
Online Access:https://journals.lww.com/10.4103/tjps.tjps_20_24
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