M2-ApoBDs as a therapeutic strategy for systemic lupus erythematosus: targeted macrophage reprogramming and treg differentiation

M2-ApoBDs as a therapeutic strategy for systemic lupus erythematosus: targeted macrophage reprogramming and treg differentiation

Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that affects various organs and systems, significantly impacting patients’ health and quality of life. Conventional drugs, including glucocorticoids and standard immunosuppressive drugs, may not be enough to achieve a satis...

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Main Authors: Juan Ji, Shaoying Yang, Yongxin Xu, Qian He, Qian Liang, Guijuan Feng, Yunfei Xia, Mei Yang, Yuting Huang, Junling Yang, Chen Dong, Rui Zhao, Yunan Wang, Genkai Guo, Xiaoqi Sha, Jing Li, Yuehua Guo, Zhifeng Gu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Systemic lupus erythematosus
Apoptotic bodies
Macrophages reprogramming
Targeted therapy
Immune regulation
Online Access:https://doi.org/10.1186/s12951-025-03437-4
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