Cytokine-Leukotriene Receptor Interactions
Biochemical and pharmacological studies have identified the structure of leukotrienes, the pathways that lead to their synthesis, and the signaling events they trigger when they interact with their cognate receptors. A privileged interaction exists between these lipid mediators and another group of...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2007.183 |
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| _version_ | 1832556600118738944 |
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| author | Marek Rola-Pleszczynski Jana Stankova |
| author_facet | Marek Rola-Pleszczynski Jana Stankova |
| author_sort | Marek Rola-Pleszczynski |
| collection | DOAJ |
| description | Biochemical and pharmacological studies have identified the structure of leukotrienes, the pathways that lead to their synthesis, and the signaling events they trigger when they interact with their cognate receptors. A privileged interaction exists between these lipid mediators and another group of molecules essential for inflammation and immune modulation, namely, cytokines. Whereas leukotrienes can trigger the synthesis and release of selected cytokines in distinct cell populations, many cytokines can affect cellular responsiveness to leukotrienes by modulating leukotriene receptor expression. As we progressively begin to unravel these complex interactions, new areas of cell-cell communication and eventual therapeutic interventions will emerge. |
| format | Article |
| id | doaj-art-274695b522a54a71afa8de929b236c7a |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-274695b522a54a71afa8de929b236c7a2025-02-03T05:44:47ZengWileyThe Scientific World Journal1537-744X2007-01-0171348135810.1100/tsw.2007.183Cytokine-Leukotriene Receptor InteractionsMarek Rola-Pleszczynski0Jana Stankova1Immunology Division, Department of Pediatrics, Faculty of Medicine, Université de Sherbrooke, Sherbrooke QC, J1H 5N4, CanadaImmunology Division, Department of Pediatrics, Faculty of Medicine, Université de Sherbrooke, Sherbrooke QC, J1H 5N4, CanadaBiochemical and pharmacological studies have identified the structure of leukotrienes, the pathways that lead to their synthesis, and the signaling events they trigger when they interact with their cognate receptors. A privileged interaction exists between these lipid mediators and another group of molecules essential for inflammation and immune modulation, namely, cytokines. Whereas leukotrienes can trigger the synthesis and release of selected cytokines in distinct cell populations, many cytokines can affect cellular responsiveness to leukotrienes by modulating leukotriene receptor expression. As we progressively begin to unravel these complex interactions, new areas of cell-cell communication and eventual therapeutic interventions will emerge.http://dx.doi.org/10.1100/tsw.2007.183 |
| spellingShingle | Marek Rola-Pleszczynski Jana Stankova Cytokine-Leukotriene Receptor Interactions The Scientific World Journal |
| title | Cytokine-Leukotriene Receptor Interactions |
| title_full | Cytokine-Leukotriene Receptor Interactions |
| title_fullStr | Cytokine-Leukotriene Receptor Interactions |
| title_full_unstemmed | Cytokine-Leukotriene Receptor Interactions |
| title_short | Cytokine-Leukotriene Receptor Interactions |
| title_sort | cytokine leukotriene receptor interactions |
| url | http://dx.doi.org/10.1100/tsw.2007.183 |
| work_keys_str_mv | AT marekrolapleszczynski cytokineleukotrienereceptorinteractions AT janastankova cytokineleukotrienereceptorinteractions |