Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b
The cardiovascular system adaptation occurs during pregnancy to ensure adequate maternal circulation. Progesterone (P4) is widely used in hormone therapy to support pregnancy, but little is known about its effects on maternal cardiac function. In this study, we investigated the cardiac repolarizatio...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Cardiovascular Therapeutics |
| Online Access: | http://dx.doi.org/10.1155/2022/7145699 |
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| author | Shuang Liang Yu-Shuang Sun Lu Li Yao Long Meng Wang Hou-Zhi Yang Chun-Di Li Yan Wang Shan-Shan Li Xu Chen Xin Jin |
| author_facet | Shuang Liang Yu-Shuang Sun Lu Li Yao Long Meng Wang Hou-Zhi Yang Chun-Di Li Yan Wang Shan-Shan Li Xu Chen Xin Jin |
| author_sort | Shuang Liang |
| collection | DOAJ |
| description | The cardiovascular system adaptation occurs during pregnancy to ensure adequate maternal circulation. Progesterone (P4) is widely used in hormone therapy to support pregnancy, but little is known about its effects on maternal cardiac function. In this study, we investigated the cardiac repolarization and ion channel expression in pregnant subjects and mice models and studied the effects of P4 administrations on these pregnancy-mediated adaptations. P4 administrations shortened the prolongation of QTC intervals and action potential duration (APD) that occurred during pregnancy, which was mainly attributable to the reduction in the voltage-gated potassium (Kv) current under basal conditions. In vitro studies indicated that P4 regulated the Kv2.1 channel in a bidirectional manner. At a low dose (1 μM), P4 induced upregulation of Kv2.1 through P4 receptor, while at a higher dose (5 μM), P4 downregulated Kv2.1 by targeting microRNA-29b (miR-29b). Our data showed that P4 modulated maternal cardiac repolarization by regulating Kv2.1 channel activity during pregnancy. Kv2.1, as well as miR-29b, might be used as potential therapeutic targets for adaptations of the maternal cardiovascular system or evaluation of progesterone medication during pregnancy. |
| format | Article |
| id | doaj-art-274366c7c2ec42b4b362e98aa1af5554 |
| institution | Kabale University |
| issn | 1755-5922 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiovascular Therapeutics |
| spelling | doaj-art-274366c7c2ec42b4b362e98aa1af55542025-02-03T01:22:44ZengWileyCardiovascular Therapeutics1755-59222022-01-01202210.1155/2022/7145699Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29bShuang Liang0Yu-Shuang Sun1Lu Li2Yao Long3Meng Wang4Hou-Zhi Yang5Chun-Di Li6Yan Wang7Shan-Shan Li8Xu Chen9Xin Jin10School of MedicineDepartment of Biopharmaceutical SciencesSchool of MedicineSchool of MedicineTianjin Medical UniversityTianjin Medical UniversityTianjin Medical UniversityTianjin Medical UniversitySchool of MedicineSchool of MedicineSchool of MedicineThe cardiovascular system adaptation occurs during pregnancy to ensure adequate maternal circulation. Progesterone (P4) is widely used in hormone therapy to support pregnancy, but little is known about its effects on maternal cardiac function. In this study, we investigated the cardiac repolarization and ion channel expression in pregnant subjects and mice models and studied the effects of P4 administrations on these pregnancy-mediated adaptations. P4 administrations shortened the prolongation of QTC intervals and action potential duration (APD) that occurred during pregnancy, which was mainly attributable to the reduction in the voltage-gated potassium (Kv) current under basal conditions. In vitro studies indicated that P4 regulated the Kv2.1 channel in a bidirectional manner. At a low dose (1 μM), P4 induced upregulation of Kv2.1 through P4 receptor, while at a higher dose (5 μM), P4 downregulated Kv2.1 by targeting microRNA-29b (miR-29b). Our data showed that P4 modulated maternal cardiac repolarization by regulating Kv2.1 channel activity during pregnancy. Kv2.1, as well as miR-29b, might be used as potential therapeutic targets for adaptations of the maternal cardiovascular system or evaluation of progesterone medication during pregnancy.http://dx.doi.org/10.1155/2022/7145699 |
| spellingShingle | Shuang Liang Yu-Shuang Sun Lu Li Yao Long Meng Wang Hou-Zhi Yang Chun-Di Li Yan Wang Shan-Shan Li Xu Chen Xin Jin Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b Cardiovascular Therapeutics |
| title | Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b |
| title_full | Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b |
| title_fullStr | Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b |
| title_full_unstemmed | Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b |
| title_short | Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b |
| title_sort | progesterone changes the pregnancy induced adaptation of cardiomyocyte kv2 1 channels via microrna 29b |
| url | http://dx.doi.org/10.1155/2022/7145699 |
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