The relationship between radiographic disc calcification score and FGF4L2 genotype in dachshunds
Abstract Background The relationship between radiographic disc calcification score and FGF4L2 genotype has been reported in only a small number of dachshunds. Hypothesis A genotype with either 0 or 1 FGF4L2 copy will be associated with a lower number of calcified discs (lower K‐n) compared with a ge...
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Wiley
2025-01-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.17281 |
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| author | Stacey Sullivan David Redden Froydis Hardeng Malin Sundqvist Michelle Kutzler |
| author_facet | Stacey Sullivan David Redden Froydis Hardeng Malin Sundqvist Michelle Kutzler |
| author_sort | Stacey Sullivan |
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| description | Abstract Background The relationship between radiographic disc calcification score and FGF4L2 genotype has been reported in only a small number of dachshunds. Hypothesis A genotype with either 0 or 1 FGF4L2 copy will be associated with a lower number of calcified discs (lower K‐n) compared with a genotype with 2 FGF4L2 copies. Animals Dachshunds registered with the Norwegian or Finnish Kennel Clubs for which both K‐n and FGF4L2 genotype are known (n = 407). Methods Retrospective study (2012‐2024). The frequency and percentage of dachshunds within each K‐n group (K0, K1/2, K3/4, K5+) by FGF4L2 genotype (FGF4L2/FGF4L2, N/FGF4L2, N/N) were reported. The K‐n distribution differences among genotypes were analyzed by the Cochran‐Mantel‐Haenszel test in SAS 9.4. Significance was defined as P < .05. Results A difference in K‐n distribution was found between dachshunds that have 0 or 2 FGF4L2 copies. However, no difference was found in the K‐n distribution between dachshunds that have 1 or 2 FGF4L2 copies. Conclusions and Clinical Importance Most dachshunds with 1 FGF4L2 copy have radiographic disc calcification scores that are associated with substantially lower risk of symptomatic disc disease. Radiographic disc calcification scores are similar in dachshunds with 0 and 1 FGF4L2 copies. Given the high allele frequency of FGF4L2, breeding to produce progeny with 1 FGF4L2 copy is expected to be a more achievable short‐term goal for dachshund spinal health breeding programs than breeding for 0 copies. It is recommended that both K‐n and FGF4L2 genotype status be considered when choosing dachshund breeding stock. |
| format | Article |
| id | doaj-art-27405f85f2e24e25ab1ac71c105cfd43 |
| institution | Kabale University |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-27405f85f2e24e25ab1ac71c105cfd432025-01-27T15:22:41ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762025-01-01391n/an/a10.1111/jvim.17281The relationship between radiographic disc calcification score and FGF4L2 genotype in dachshundsStacey Sullivan0David Redden1Froydis Hardeng2Malin Sundqvist3Michelle Kutzler4College of Veterinary Medicine, Clinical Sciences Auburn University Auburn Alabama USACollege of Osteopathic Medicine Auburn University Auburn Alabama USANorwegian Federation of Dachshund Clubs Olso NorwaySwedish Dachshund Club Stockholm SwedenAnimal Sciences Oregon State University Corvallis Oregon USAAbstract Background The relationship between radiographic disc calcification score and FGF4L2 genotype has been reported in only a small number of dachshunds. Hypothesis A genotype with either 0 or 1 FGF4L2 copy will be associated with a lower number of calcified discs (lower K‐n) compared with a genotype with 2 FGF4L2 copies. Animals Dachshunds registered with the Norwegian or Finnish Kennel Clubs for which both K‐n and FGF4L2 genotype are known (n = 407). Methods Retrospective study (2012‐2024). The frequency and percentage of dachshunds within each K‐n group (K0, K1/2, K3/4, K5+) by FGF4L2 genotype (FGF4L2/FGF4L2, N/FGF4L2, N/N) were reported. The K‐n distribution differences among genotypes were analyzed by the Cochran‐Mantel‐Haenszel test in SAS 9.4. Significance was defined as P < .05. Results A difference in K‐n distribution was found between dachshunds that have 0 or 2 FGF4L2 copies. However, no difference was found in the K‐n distribution between dachshunds that have 1 or 2 FGF4L2 copies. Conclusions and Clinical Importance Most dachshunds with 1 FGF4L2 copy have radiographic disc calcification scores that are associated with substantially lower risk of symptomatic disc disease. Radiographic disc calcification scores are similar in dachshunds with 0 and 1 FGF4L2 copies. Given the high allele frequency of FGF4L2, breeding to produce progeny with 1 FGF4L2 copy is expected to be a more achievable short‐term goal for dachshund spinal health breeding programs than breeding for 0 copies. It is recommended that both K‐n and FGF4L2 genotype status be considered when choosing dachshund breeding stock.https://doi.org/10.1111/jvim.1728112‐FGF4CDDYchondrodystrophydisc calcificationK‐numbertype 1 intervertebral disc disease |
| spellingShingle | Stacey Sullivan David Redden Froydis Hardeng Malin Sundqvist Michelle Kutzler The relationship between radiographic disc calcification score and FGF4L2 genotype in dachshunds Journal of Veterinary Internal Medicine 12‐FGF4 CDDY chondrodystrophy disc calcification K‐number type 1 intervertebral disc disease |
| title | The relationship between radiographic disc calcification score and FGF4L2 genotype in dachshunds |
| title_full | The relationship between radiographic disc calcification score and FGF4L2 genotype in dachshunds |
| title_fullStr | The relationship between radiographic disc calcification score and FGF4L2 genotype in dachshunds |
| title_full_unstemmed | The relationship between radiographic disc calcification score and FGF4L2 genotype in dachshunds |
| title_short | The relationship between radiographic disc calcification score and FGF4L2 genotype in dachshunds |
| title_sort | relationship between radiographic disc calcification score and fgf4l2 genotype in dachshunds |
| topic | 12‐FGF4 CDDY chondrodystrophy disc calcification K‐number type 1 intervertebral disc disease |
| url | https://doi.org/10.1111/jvim.17281 |
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