Identification of novel inhibitors of the transcriptional coactivator MRTF-A for HCC therapy

Identification of novel inhibitors of the transcriptional coactivator MRTF-A for HCC therapy

Myocardin-related transcription factor A (MRTF-A) is a coactivator of serum response factor (SRF), which regulates the expression of genes involved in cell proliferation, migration, and differentiation and has been implicated in hepatocellular carcinoma (HCC) progression. We recently established inh...

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Bibliographic Details
Main Authors: Miriam Jasmin Franz, Pia Wenisch, Petra Wohlleben, Laura Rupprecht, Vladimir Chubanov, Thomas Gudermann, Salla Kyheröinen, Maria Kristina Vartiainen, Markus R. Heinrich, Susanne Muehlich
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
MKL1
MRTF
SRF
TRPM7
HCC
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000973
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