Cu2O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible light

Cu2O quantum dots redefining photodynamic therapy with one-minute pathogen inactivation under visible light

This work utilizes tailored – Cu2O quantum dots (QDs) to demonstrate unprecedented pathogen photo-inactivation. The superior ROS production of the QDs synthesized at 180 °C with a size of 8.10 nm resulted in a 99.98 % reduction of MRSA, 99.78 % of Klebsiella pneumoniae, and 98.92 % of SARS-CoV Delta...

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Main Authors: Azzah Dyah Pramata, Farhan Aryo Hutomo, Febriyansyah Saputra, Paundra Rizky Pratama, Taras Geonovive De Yenarosa, Sutarsis, Sigit Tri Wicaksono, Agung Purniawan, Revianny Nidom, Shao-Yang Hu
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:Case Studies in Chemical and Environmental Engineering
Subjects:
Cu2O QDs
Pathogen
Photodynamic-therapy
Ultrafast
Selective-cytotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2666016425001550
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Summary:This work utilizes tailored – Cu2O quantum dots (QDs) to demonstrate unprecedented pathogen photo-inactivation. The superior ROS production of the QDs synthesized at 180 °C with a size of 8.10 nm resulted in a 99.98 % reduction of MRSA, 99.78 % of Klebsiella pneumoniae, and 98.92 % of SARS-CoV Delta within 1 min under visible light. Cu2O QDs efficiently reduced 99.25 % viability of 4T1 cancer cells in 15 min while maintaining more than 85 % viability in healthy HEK 293 cells, underlining its selectivity. This finding may establish Cu2O QDs as the next-generation anti-pathogen agents for advanced photodynamic therapy (PDT), biomedical sterilization, and hospital applications.
ISSN:2666-0164

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