An overview of SARS-COV-2: Virology, Epidemiology, Pathogenesis and Treatment
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a causative agent of COVID-19 infections. In late December, 2019 emergence and pandemic outbreak of SARS-CoV-2 virus has created serious health threat globally, unlike emergence of SARS-CoV in 2002, and Middle East Respiratory Syndrom...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
ResearchersLinks, Ltd
2020-06-01
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| Series: | Novel Research in Microbiology Journal |
| Subjects: | |
| Online Access: | https://nrmj.journals.ekb.eg/article_95319_1f1d6cdb4b9644aa0e8f1cfbb8e373cc.pdf |
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| Summary: | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a causative agent of COVID-19
infections. In late December, 2019 emergence and pandemic outbreak of SARS-CoV-2 virus has created serious
health threat globally, unlike emergence of SARS-CoV in 2002, and Middle East Respiratory Syndrome (MERSCoV) in 2012. Globally, about 4,434,653 confirmed cases of COVID-19 infections are reported including 302,169
deaths. Wild animals’ bat, snakes, and pangolins are potential sources of this virus, based on the sequence
homology of these animals and the nucleic acid of SARS-CoV-2 virus isolated from infected persons. Human
infection occurs due to the inhalation of respiratory droplets, which mainly infects the lower respiratory tract
causing a mild flu like symptoms that may extend to severe pneumonia. Currently, there are no any vaccines or
antiviral drugs against this virus. Treatment of patients is based mainly on symptomatic management. The aims of
the present study were to summarize the information on the origin, evolution, structure and genomes,
epidemiology, molecular immunopathogenesis, and diagnostic approaches of the SARS-CoV-2 coronavirus.
Moreover, we discuss the current approaches, progress in vaccine development, and the antiviral therapies to cope
with COVID-19 infection. Thus, the information and data gathered on coronavirus will be helpful in
understanding all the aspects on SARS-CoV-2 virus, and helps to reduce the global health threat and economic
impact. |
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| ISSN: | 2537-0286 2537-0294 |