Combined MR Volumetry and T2* Relaxometry Reveals the Olfactory System as an Iron-Dependent Structure Affected by Radiation
<b>Background/Objectives:</b> Radiation therapy can often lead to structural and functional changes in the brain resulting in radiation-induced brain injury. This study investigates the MRI-detectable effects of whole-brain irradiation across all neuroanatomical structures in adult mice,...
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2025-04-01
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| author | Njenga R. Kamau Michelle R. Tamplin Chu-Yu Lee Eric D. Axelson Isabella M. Grumbach Michael S. Petronek |
| author_facet | Njenga R. Kamau Michelle R. Tamplin Chu-Yu Lee Eric D. Axelson Isabella M. Grumbach Michael S. Petronek |
| author_sort | Njenga R. Kamau |
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| description | <b>Background/Objectives:</b> Radiation therapy can often lead to structural and functional changes in the brain resulting in radiation-induced brain injury. This study investigates the MRI-detectable effects of whole-brain irradiation across all neuroanatomical structures in adult mice, with a specific focus on T2* MRI measurements, to evaluate regions that may be particularly sensitive to iron accumulation. <b>Methods:</b> One year following irradiation or sham treatment, mice were imaged with a 7T MRI to evaluate changes in regional volume and T2* relaxation times across more than 652 neuroanatomical using the DSURQE mouse brain atlas. <b>Results:</b> Statistical analysis identified 301 altered regions with respect to regional volume and 85 regions with respect to T2* relaxation showing significant differences relative to the control group (<i>p</i> < 0.05). Further data refinement, including the consolidation of redundant, bi-lateral structures revealed 18 subregions with significant changes in both volume and T2*. The data refinement revealed that the most represented system was the olfactory system (8/18 regions, 44%). The olfactory regions also showed the most pronounced changes and greatest correlation between the two metrics. <b>Conclusions:</b> These findings are suggestive that ionizing radiation may cause a pronounced disruption in the olfactory system that coincides with potential iron accumulation. |
| format | Article |
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| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-2730f7b9b1694a4e8c9fd88eec6f2d932025-08-20T02:28:27ZengMDPI AGNeurology International2035-83772025-04-011745310.3390/neurolint17040053Combined MR Volumetry and T2* Relaxometry Reveals the Olfactory System as an Iron-Dependent Structure Affected by RadiationNjenga R. Kamau0Michelle R. Tamplin1Chu-Yu Lee2Eric D. Axelson3Isabella M. Grumbach4Michael S. Petronek5Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USADepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USADepartment of Radiology, University of Iowa, Iowa City, IA 52242, USADepartment of Psychiatry, University of Iowa, Iowa City, IA 52242, USADepartment of Internal Medicine, University of Iowa, Iowa City, IA 52242, USADepartment of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA<b>Background/Objectives:</b> Radiation therapy can often lead to structural and functional changes in the brain resulting in radiation-induced brain injury. This study investigates the MRI-detectable effects of whole-brain irradiation across all neuroanatomical structures in adult mice, with a specific focus on T2* MRI measurements, to evaluate regions that may be particularly sensitive to iron accumulation. <b>Methods:</b> One year following irradiation or sham treatment, mice were imaged with a 7T MRI to evaluate changes in regional volume and T2* relaxation times across more than 652 neuroanatomical using the DSURQE mouse brain atlas. <b>Results:</b> Statistical analysis identified 301 altered regions with respect to regional volume and 85 regions with respect to T2* relaxation showing significant differences relative to the control group (<i>p</i> < 0.05). Further data refinement, including the consolidation of redundant, bi-lateral structures revealed 18 subregions with significant changes in both volume and T2*. The data refinement revealed that the most represented system was the olfactory system (8/18 regions, 44%). The olfactory regions also showed the most pronounced changes and greatest correlation between the two metrics. <b>Conclusions:</b> These findings are suggestive that ionizing radiation may cause a pronounced disruption in the olfactory system that coincides with potential iron accumulation.https://www.mdpi.com/2035-8377/17/4/53radiation-induced brain injuryiron metabolismT2* mappingolfactory system |
| spellingShingle | Njenga R. Kamau Michelle R. Tamplin Chu-Yu Lee Eric D. Axelson Isabella M. Grumbach Michael S. Petronek Combined MR Volumetry and T2* Relaxometry Reveals the Olfactory System as an Iron-Dependent Structure Affected by Radiation Neurology International radiation-induced brain injury iron metabolism T2* mapping olfactory system |
| title | Combined MR Volumetry and T2* Relaxometry Reveals the Olfactory System as an Iron-Dependent Structure Affected by Radiation |
| title_full | Combined MR Volumetry and T2* Relaxometry Reveals the Olfactory System as an Iron-Dependent Structure Affected by Radiation |
| title_fullStr | Combined MR Volumetry and T2* Relaxometry Reveals the Olfactory System as an Iron-Dependent Structure Affected by Radiation |
| title_full_unstemmed | Combined MR Volumetry and T2* Relaxometry Reveals the Olfactory System as an Iron-Dependent Structure Affected by Radiation |
| title_short | Combined MR Volumetry and T2* Relaxometry Reveals the Olfactory System as an Iron-Dependent Structure Affected by Radiation |
| title_sort | combined mr volumetry and t2 relaxometry reveals the olfactory system as an iron dependent structure affected by radiation |
| topic | radiation-induced brain injury iron metabolism T2* mapping olfactory system |
| url | https://www.mdpi.com/2035-8377/17/4/53 |
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