GinExtraMed: Focus on <i>Rosa canina</i> L. Extract Encapsulated into Glycethosomes and Allanthosomes for Accelerating Skin Wound Healing
<b>Background/Objectives:</b> Over the last decade, the development of innovative wound products has continued to be a focus of intense research to meet the huge demand of patients. The aim of this work was to develop novel medicated Spanish broom wound dressings capable of releasing <...
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2025-05-01
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| Online Access: | https://www.mdpi.com/1999-4923/17/5/632 |
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| author | Martina Rossi Simone Rossello Valentina Sallustio Manuela Mandrone Teresa Cerchiara Ilaria Chiocchio Giuseppe Chidichimo Michele Protti Laura Mercolini Barbara Luppi Federica Bigucci Angela Abruzzo Concettina Cappadone |
| author_facet | Martina Rossi Simone Rossello Valentina Sallustio Manuela Mandrone Teresa Cerchiara Ilaria Chiocchio Giuseppe Chidichimo Michele Protti Laura Mercolini Barbara Luppi Federica Bigucci Angela Abruzzo Concettina Cappadone |
| author_sort | Martina Rossi |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> Over the last decade, the development of innovative wound products has continued to be a focus of intense research to meet the huge demand of patients. The aim of this work was to develop novel medicated Spanish broom wound dressings capable of releasing <i>Rosa canina</i> extract, recognized for its high antioxidant activity. <b>Methods:</b><i>Rosa canina</i> extract was encapsulated in two different nanocarriers, namely glycethosomes and allanthosomes. The physico-chemical and functional characteristics of the obtained vesicles were described, including their size, particle size distribution, ζ potential, and encapsulation efficiency (EE). In addition, vesicles cytotoxicity and cell proliferation were evaluated on human fibroblasts. Furthermore, loaded vesicles were sunk into Spanish broom dressings, analyzed by confocal microscopy, and, finally, evaluated for their wound healing ability by scratch test. <b>Results:</b> Both carriers are nanometric in size, with a good EE (>70%), and a negative ζ potential. Additionally, vesicles are biosafe, non-cytotoxic, and lead to complete closure of the scratch in about 30 h. <b>Conclusions:</b> The findings showed that the developed Spanish broom dressings have the potential to be an efficient and innovative wound care product for accelerating skin wounds. |
| format | Article |
| id | doaj-art-272e3de21c76406a89c276a4daecb8cb |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-272e3de21c76406a89c276a4daecb8cb2025-08-20T03:47:54ZengMDPI AGPharmaceutics1999-49232025-05-0117563210.3390/pharmaceutics17050632GinExtraMed: Focus on <i>Rosa canina</i> L. Extract Encapsulated into Glycethosomes and Allanthosomes for Accelerating Skin Wound HealingMartina Rossi0Simone Rossello1Valentina Sallustio2Manuela Mandrone3Teresa Cerchiara4Ilaria Chiocchio5Giuseppe Chidichimo6Michele Protti7Laura Mercolini8Barbara Luppi9Federica Bigucci10Angela Abruzzo11Concettina Cappadone12Drug Delivery Research Laboratory, Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via San Donato 19/2, 40127 Bologna, ItalyDrug Delivery Research Laboratory, Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via San Donato 19/2, 40127 Bologna, ItalyDrug Delivery Research Laboratory, Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via San Donato 19/2, 40127 Bologna, ItalyPharmaceutical Botany Laboratory, Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Irnerio 42, 40126 Bologna, ItalyDrug Delivery Research Laboratory, Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via San Donato 19/2, 40127 Bologna, ItalyPharmaceutical Botany Laboratory, Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Irnerio 42, 40126 Bologna, ItalyDepartment of Chemistry and Chemical Technologies, Università della Calabria, Via P. Bucci, 87036 Arcavacata di Rende, ItalyPharmaco-Toxicological Analysis (PTA Laboratory), Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, ItalyPharmaco-Toxicological Analysis (PTA Laboratory), Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, ItalyDrug Delivery Research Laboratory, Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via San Donato 19/2, 40127 Bologna, ItalyDrug Delivery Research Laboratory, Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via San Donato 19/2, 40127 Bologna, ItalyDrug Delivery Research Laboratory, Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via San Donato 19/2, 40127 Bologna, ItalyPharmaceutical Biochemistry Laboratory, Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy<b>Background/Objectives:</b> Over the last decade, the development of innovative wound products has continued to be a focus of intense research to meet the huge demand of patients. The aim of this work was to develop novel medicated Spanish broom wound dressings capable of releasing <i>Rosa canina</i> extract, recognized for its high antioxidant activity. <b>Methods:</b><i>Rosa canina</i> extract was encapsulated in two different nanocarriers, namely glycethosomes and allanthosomes. The physico-chemical and functional characteristics of the obtained vesicles were described, including their size, particle size distribution, ζ potential, and encapsulation efficiency (EE). In addition, vesicles cytotoxicity and cell proliferation were evaluated on human fibroblasts. Furthermore, loaded vesicles were sunk into Spanish broom dressings, analyzed by confocal microscopy, and, finally, evaluated for their wound healing ability by scratch test. <b>Results:</b> Both carriers are nanometric in size, with a good EE (>70%), and a negative ζ potential. Additionally, vesicles are biosafe, non-cytotoxic, and lead to complete closure of the scratch in about 30 h. <b>Conclusions:</b> The findings showed that the developed Spanish broom dressings have the potential to be an efficient and innovative wound care product for accelerating skin wounds.https://www.mdpi.com/1999-4923/17/5/632<i>Rosa canina</i> L. extractSpanish broomwound dressingsencapsulationglycethosomesallanthosomes |
| spellingShingle | Martina Rossi Simone Rossello Valentina Sallustio Manuela Mandrone Teresa Cerchiara Ilaria Chiocchio Giuseppe Chidichimo Michele Protti Laura Mercolini Barbara Luppi Federica Bigucci Angela Abruzzo Concettina Cappadone GinExtraMed: Focus on <i>Rosa canina</i> L. Extract Encapsulated into Glycethosomes and Allanthosomes for Accelerating Skin Wound Healing Pharmaceutics <i>Rosa canina</i> L. extract Spanish broom wound dressings encapsulation glycethosomes allanthosomes |
| title | GinExtraMed: Focus on <i>Rosa canina</i> L. Extract Encapsulated into Glycethosomes and Allanthosomes for Accelerating Skin Wound Healing |
| title_full | GinExtraMed: Focus on <i>Rosa canina</i> L. Extract Encapsulated into Glycethosomes and Allanthosomes for Accelerating Skin Wound Healing |
| title_fullStr | GinExtraMed: Focus on <i>Rosa canina</i> L. Extract Encapsulated into Glycethosomes and Allanthosomes for Accelerating Skin Wound Healing |
| title_full_unstemmed | GinExtraMed: Focus on <i>Rosa canina</i> L. Extract Encapsulated into Glycethosomes and Allanthosomes for Accelerating Skin Wound Healing |
| title_short | GinExtraMed: Focus on <i>Rosa canina</i> L. Extract Encapsulated into Glycethosomes and Allanthosomes for Accelerating Skin Wound Healing |
| title_sort | ginextramed focus on i rosa canina i l extract encapsulated into glycethosomes and allanthosomes for accelerating skin wound healing |
| topic | <i>Rosa canina</i> L. extract Spanish broom wound dressings encapsulation glycethosomes allanthosomes |
| url | https://www.mdpi.com/1999-4923/17/5/632 |
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