Children with idiopathic short stature and growth hormone deficiency exhibit similar changes in gut microbiota
Children with idiopathic short stature (ISS) and growth hormone deficiency (GHD) exhibit imbalances in gut microbiota (GM), and the latter is related to endocrine hormones (such as insulin-like growth factor 1 (IGF-1)). The current study investigated the compositional and functional variations in GM...
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The Japan Endocrine Society
2025-07-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/72/7/72_EJ24-0615/_html/-char/en |
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| author | Jing Han Congfu Huang Lingjuan Meng Hui Wu Dongming Meng |
| author_facet | Jing Han Congfu Huang Lingjuan Meng Hui Wu Dongming Meng |
| author_sort | Jing Han |
| collection | DOAJ |
| description | Children with idiopathic short stature (ISS) and growth hormone deficiency (GHD) exhibit imbalances in gut microbiota (GM), and the latter is related to endocrine hormones (such as insulin-like growth factor 1 (IGF-1)). The current study investigated the compositional and functional variations in GM between children with ISS and GHD, employing 16S rRNA sequencing technology. Sequencing results from 15 children with ISS and 18 children with GHD indicated no significant differences in GM alpha diversity or phylum-level diversity between the ISS and GHD groups. At the genus level, the abundance of Terrisporobacter was significantly greater in the ISS group compared to the GHD group, whereas the abundance of Acidovorax was reduced. The abundance of Prevotella stercorea and uncultured Sutterella sp. at the species level was significantly lower in the ISS group compared to the GHD group. The third level (L3) of the Kyoto Encyclopedia of Genes and Genomes (KEGG) database revealed functional variations in GM, with children in the ISS group having higher levels of intestinal bacteria Mobility Proteins and Background Chemotaxis. Despite these differences, the overall composition and function of GM between ISS and GHD children were not significantly different, indicating that the mechanisms by which GM influences the growth and development of children in both groups may be similar. This study was registered with the Medical Research Registration and Record System with the registration number MR-44-24-045472. |
| format | Article |
| id | doaj-art-272d6f062ebb4bb4b58fe21d5ca6cb78 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-272d6f062ebb4bb4b58fe21d5ca6cb782025-08-20T03:30:01ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402025-07-0172779179910.1507/endocrj.EJ24-0615endocrjChildren with idiopathic short stature and growth hormone deficiency exhibit similar changes in gut microbiotaJing Han0Congfu Huang1Lingjuan Meng2Hui Wu3Dongming Meng4Department of Pediatrics, Longgang Maternity and Child Institute of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen 518172, ChinaDepartment of Pediatrics, Longgang Maternity and Child Institute of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen 518172, ChinaDepartment of Pediatrics, Longgang Maternity and Child Institute of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen 518172, ChinaDepartment of Pediatrics, Hexian Memorial Affiliated Hospital of Southern Medical University, Guangzhou 511400, ChinaDepartment of Pediatrics, Longgang Maternity and Child Institute of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen 518172, ChinaChildren with idiopathic short stature (ISS) and growth hormone deficiency (GHD) exhibit imbalances in gut microbiota (GM), and the latter is related to endocrine hormones (such as insulin-like growth factor 1 (IGF-1)). The current study investigated the compositional and functional variations in GM between children with ISS and GHD, employing 16S rRNA sequencing technology. Sequencing results from 15 children with ISS and 18 children with GHD indicated no significant differences in GM alpha diversity or phylum-level diversity between the ISS and GHD groups. At the genus level, the abundance of Terrisporobacter was significantly greater in the ISS group compared to the GHD group, whereas the abundance of Acidovorax was reduced. The abundance of Prevotella stercorea and uncultured Sutterella sp. at the species level was significantly lower in the ISS group compared to the GHD group. The third level (L3) of the Kyoto Encyclopedia of Genes and Genomes (KEGG) database revealed functional variations in GM, with children in the ISS group having higher levels of intestinal bacteria Mobility Proteins and Background Chemotaxis. Despite these differences, the overall composition and function of GM between ISS and GHD children were not significantly different, indicating that the mechanisms by which GM influences the growth and development of children in both groups may be similar. This study was registered with the Medical Research Registration and Record System with the registration number MR-44-24-045472.https://www.jstage.jst.go.jp/article/endocrj/72/7/72_EJ24-0615/_html/-char/en16s rrna sequencingidiopathic short stature (iss)growth hormone deficiency (ghd)gut microbiota (gm)kyoto encyclopedia of genes and genomes (kegg) function classification |
| spellingShingle | Jing Han Congfu Huang Lingjuan Meng Hui Wu Dongming Meng Children with idiopathic short stature and growth hormone deficiency exhibit similar changes in gut microbiota Endocrine Journal 16s rrna sequencing idiopathic short stature (iss) growth hormone deficiency (ghd) gut microbiota (gm) kyoto encyclopedia of genes and genomes (kegg) function classification |
| title | Children with idiopathic short stature and growth hormone deficiency exhibit similar changes in gut microbiota |
| title_full | Children with idiopathic short stature and growth hormone deficiency exhibit similar changes in gut microbiota |
| title_fullStr | Children with idiopathic short stature and growth hormone deficiency exhibit similar changes in gut microbiota |
| title_full_unstemmed | Children with idiopathic short stature and growth hormone deficiency exhibit similar changes in gut microbiota |
| title_short | Children with idiopathic short stature and growth hormone deficiency exhibit similar changes in gut microbiota |
| title_sort | children with idiopathic short stature and growth hormone deficiency exhibit similar changes in gut microbiota |
| topic | 16s rrna sequencing idiopathic short stature (iss) growth hormone deficiency (ghd) gut microbiota (gm) kyoto encyclopedia of genes and genomes (kegg) function classification |
| url | https://www.jstage.jst.go.jp/article/endocrj/72/7/72_EJ24-0615/_html/-char/en |
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