Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Abstract Recent advances in lysosome‐targeting degradation technologies have introduced strategies to regulate therapeutic membrane proteins (MPs), potentially transforming treatment paradigms. However, challenges persist, including limited degradation precision due to the broad distribution of lyso...

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Bibliographic Details
Main Authors: Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
cancer therapy
molecular engineering
mRNA
precision medicine
protein degradation
Online Access:https://doi.org/10.1002/advs.202501222
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