Dual role of Metrnl: exercise-induced benefits and potential cancer implications
Metrnl (Meteorin-like), a protein elevated by exercise, supports metabolic regulation, inflammation reduction and glucose homeostasis. While exercise is a cornerstone of cancer prevention and management, recent findings suggest that Metrnl plays a dual role, potentially impairing T-cell function in...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2025-05-01
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| Series: | Journal for ImmunoTherapy of Cancer |
| Online Access: | https://jitc.bmj.com/content/13/5/e011666.full |
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| _version_ | 1849728618491543552 |
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| author | Hamid Alizadeh |
| author_facet | Hamid Alizadeh |
| author_sort | Hamid Alizadeh |
| collection | DOAJ |
| description | Metrnl (Meteorin-like), a protein elevated by exercise, supports metabolic regulation, inflammation reduction and glucose homeostasis. While exercise is a cornerstone of cancer prevention and management, recent findings suggest that Metrnl plays a dual role, potentially impairing T-cell function in the tumor microenvironment. This commentary explores the interplay between Metrnl’s systemic benefits and its local immunosuppressive effects in cancer. Despite these concerns, exercise remains broadly advantageous for patients with cancer, though further research is essential to understand Metrnl’s context-specific impacts. |
| format | Article |
| id | doaj-art-271f628517d14f15b577bb96c34b8ef6 |
| institution | DOAJ |
| issn | 2051-1426 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Journal for ImmunoTherapy of Cancer |
| spelling | doaj-art-271f628517d14f15b577bb96c34b8ef62025-08-20T03:09:31ZengBMJ Publishing GroupJournal for ImmunoTherapy of Cancer2051-14262025-05-0113510.1136/jitc-2025-011666Dual role of Metrnl: exercise-induced benefits and potential cancer implicationsHamid Alizadeh0University of Mazandaran, Babolsar, Mazandaran Province, Iran (the Islamic Republic of)Metrnl (Meteorin-like), a protein elevated by exercise, supports metabolic regulation, inflammation reduction and glucose homeostasis. While exercise is a cornerstone of cancer prevention and management, recent findings suggest that Metrnl plays a dual role, potentially impairing T-cell function in the tumor microenvironment. This commentary explores the interplay between Metrnl’s systemic benefits and its local immunosuppressive effects in cancer. Despite these concerns, exercise remains broadly advantageous for patients with cancer, though further research is essential to understand Metrnl’s context-specific impacts.https://jitc.bmj.com/content/13/5/e011666.full |
| spellingShingle | Hamid Alizadeh Dual role of Metrnl: exercise-induced benefits and potential cancer implications Journal for ImmunoTherapy of Cancer |
| title | Dual role of Metrnl: exercise-induced benefits and potential cancer implications |
| title_full | Dual role of Metrnl: exercise-induced benefits and potential cancer implications |
| title_fullStr | Dual role of Metrnl: exercise-induced benefits and potential cancer implications |
| title_full_unstemmed | Dual role of Metrnl: exercise-induced benefits and potential cancer implications |
| title_short | Dual role of Metrnl: exercise-induced benefits and potential cancer implications |
| title_sort | dual role of metrnl exercise induced benefits and potential cancer implications |
| url | https://jitc.bmj.com/content/13/5/e011666.full |
| work_keys_str_mv | AT hamidalizadeh dualroleofmetrnlexerciseinducedbenefitsandpotentialcancerimplications |