Angora Wool Asthma in Textile Industry
Up to now the exposures to hair and skin derivatives of animals have not yet been the subject of systematic studies. The observation of a clinical case has provided the opportunity for a review of the literature. The inpatient was a 49-year-old man, a carder in a textile factory, exposed to angora w...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/358271 |
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| _version_ | 1832549919115706368 |
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| author | Pietro Sartorelli Riccardo Romeo Giuseppina Coppola Roberta Nuti Valentina Paolucci |
| author_facet | Pietro Sartorelli Riccardo Romeo Giuseppina Coppola Roberta Nuti Valentina Paolucci |
| author_sort | Pietro Sartorelli |
| collection | DOAJ |
| description | Up to now the exposures to hair and skin derivatives of animals have not yet been the subject of systematic studies. The observation of a clinical case has provided the opportunity for a review of the literature. The inpatient was a 49-year-old man, a carder in a textile factory, exposed to angora wool. He noticed the appearance of dyspnea during working hours. There was no eosinophilia in blood, and the results of pulmonary function tests were normal. The nonspecific bronchial provocation test with methacholine demonstrated an abnormal bronchial reactivity. The challenge test with angora wool was positive (decrease in FEV1 of more than 40%) as well as total IGE and specific IgE to rabbit epithelium (433 KU/l and 12.1 KUA/l, resp.). Several sources of allergens were found in the rabbit, and the main allergen was represented by proteins from epithelia, urine, and saliva. Most of these proteins belong to the family of lipocalin, they function as carriers for small hydrophobic molecules (vitamins and pheromones). If the diagnosis of occupational asthma caused by animal hair and skin derivatives may be relatively easy by means of the challenge test, defining etiology is complicated because of the lack of in vitro tests. |
| format | Article |
| id | doaj-art-271af01d74fe4aa1a3851900bee2f283 |
| institution | Kabale University |
| issn | 2090-6609 2090-6617 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj-art-271af01d74fe4aa1a3851900bee2f2832025-02-03T06:08:13ZengWileyCase Reports in Immunology2090-66092090-66172012-01-01201210.1155/2012/358271358271Angora Wool Asthma in Textile IndustryPietro Sartorelli0Riccardo Romeo1Giuseppina Coppola2Roberta Nuti3Valentina Paolucci4Unit of Occupational Medicine and Toxicology, University of Siena, 16 Bracci Avenue, 53100 Siena, ItalyUnit of Occupational Medicine and Toxicology, University of Siena, 16 Bracci Avenue, 53100 Siena, ItalyUnit of Occupational Medicine and Toxicology, University of Siena, 16 Bracci Avenue, 53100 Siena, ItalyUnit of Occupational Medicine and Toxicology, University of Siena, 16 Bracci Avenue, 53100 Siena, ItalyUnit of Occupational Medicine and Toxicology, University of Siena, 16 Bracci Avenue, 53100 Siena, ItalyUp to now the exposures to hair and skin derivatives of animals have not yet been the subject of systematic studies. The observation of a clinical case has provided the opportunity for a review of the literature. The inpatient was a 49-year-old man, a carder in a textile factory, exposed to angora wool. He noticed the appearance of dyspnea during working hours. There was no eosinophilia in blood, and the results of pulmonary function tests were normal. The nonspecific bronchial provocation test with methacholine demonstrated an abnormal bronchial reactivity. The challenge test with angora wool was positive (decrease in FEV1 of more than 40%) as well as total IGE and specific IgE to rabbit epithelium (433 KU/l and 12.1 KUA/l, resp.). Several sources of allergens were found in the rabbit, and the main allergen was represented by proteins from epithelia, urine, and saliva. Most of these proteins belong to the family of lipocalin, they function as carriers for small hydrophobic molecules (vitamins and pheromones). If the diagnosis of occupational asthma caused by animal hair and skin derivatives may be relatively easy by means of the challenge test, defining etiology is complicated because of the lack of in vitro tests.http://dx.doi.org/10.1155/2012/358271 |
| spellingShingle | Pietro Sartorelli Riccardo Romeo Giuseppina Coppola Roberta Nuti Valentina Paolucci Angora Wool Asthma in Textile Industry Case Reports in Immunology |
| title | Angora Wool Asthma in Textile Industry |
| title_full | Angora Wool Asthma in Textile Industry |
| title_fullStr | Angora Wool Asthma in Textile Industry |
| title_full_unstemmed | Angora Wool Asthma in Textile Industry |
| title_short | Angora Wool Asthma in Textile Industry |
| title_sort | angora wool asthma in textile industry |
| url | http://dx.doi.org/10.1155/2012/358271 |
| work_keys_str_mv | AT pietrosartorelli angorawoolasthmaintextileindustry AT riccardoromeo angorawoolasthmaintextileindustry AT giuseppinacoppola angorawoolasthmaintextileindustry AT robertanuti angorawoolasthmaintextileindustry AT valentinapaolucci angorawoolasthmaintextileindustry |