Catechol-rich gelatin microspheres as restorative medical implants intended for inhibiting seroma formation and promoting wound healing
Seroma formation and poor wound healing are common complications of many surgeries that create anatomical dead space (i.e., mastectomy), often causing tissue infection and even necrosis. Although negative pressure drainage and tissue adhesives are investigated to alleviate fluid accumulation post-su...
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Elsevier
2024-12-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424003740 |
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| author | Xinping Wang Guoqing Wang Jianfei Wang Junqiang Xue Gaoli Liu Changjiang Fan |
| author_facet | Xinping Wang Guoqing Wang Jianfei Wang Junqiang Xue Gaoli Liu Changjiang Fan |
| author_sort | Xinping Wang |
| collection | DOAJ |
| description | Seroma formation and poor wound healing are common complications of many surgeries that create anatomical dead space (i.e., mastectomy), often causing tissue infection and even necrosis. Although negative pressure drainage and tissue adhesives are investigated to alleviate fluid accumulation post-surgery, however, their therapeutic efficacy remains unsatisfactory in most cases. Herein, the catechol-rich chemically crosslinked gelatin microspheres (ca-CGMSs) have been developed as biodegradable reconstructive implants for preventing seroma formation and concurrently promoting subcutaneous wound healing. Compared with the most representative hydrogel adhesive, i.e. commercial porcine fibrin sealant (PFS), the loosely packed ca-CGMSs with diameters range from 50 to 350 μm, provide numerous cell-adhesive interfaces and interconnected macro-pores for enhanced cell adhesion, proliferation and migration. Subcutaneous embedding trials show the in situ swelling aggregation and wet tissue adhesion of ca-CGMSs as well as their capacity in recruiting autologous cells in rat mastectomy models. The trials in rabbit mastectomy models demonstrate that, compared with PFS gluing, the implanted dried ca-CGMSs not only significantly inhibit seroma formation, but also achieve enhanced wound healing by inducing the formation of vascularized neo-tissue. The ca-CGMSs show a great potential to be the next-generation of restorative materials for both preventing seroma formation and healing subcutaneous wounds. |
| format | Article |
| id | doaj-art-2718e6007b3d4fca960997ce9fa7fb8e |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-2718e6007b3d4fca960997ce9fa7fb8e2025-08-20T01:55:30ZengElsevierMaterials Today Bio2590-00642024-12-012910131310.1016/j.mtbio.2024.101313Catechol-rich gelatin microspheres as restorative medical implants intended for inhibiting seroma formation and promoting wound healingXinping Wang0Guoqing Wang1Jianfei Wang2Junqiang Xue3Gaoli Liu4Changjiang Fan5Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao, 266021, Shandong, PR ChinaDepartment of Cardiovascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao Medical College, College of Medicine, Qingdao University, Qingdao, 266021, Shandong, PR ChinaInstitute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao, 266021, Shandong, PR ChinaDepartment of Rehabilitation Medicine, The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao, 266000, Shandong, PR ChinaDepartment of Cardiovascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao Medical College, College of Medicine, Qingdao University, Qingdao, 266021, Shandong, PR ChinaInstitute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao Medical College, Qingdao University, Qingdao, 266021, Shandong, PR China; Corresponding author. Institute for Translational Medicine The Affiliated Hospital of Qingdao University Qingdao University Qingdao, 266021, PR China.Seroma formation and poor wound healing are common complications of many surgeries that create anatomical dead space (i.e., mastectomy), often causing tissue infection and even necrosis. Although negative pressure drainage and tissue adhesives are investigated to alleviate fluid accumulation post-surgery, however, their therapeutic efficacy remains unsatisfactory in most cases. Herein, the catechol-rich chemically crosslinked gelatin microspheres (ca-CGMSs) have been developed as biodegradable reconstructive implants for preventing seroma formation and concurrently promoting subcutaneous wound healing. Compared with the most representative hydrogel adhesive, i.e. commercial porcine fibrin sealant (PFS), the loosely packed ca-CGMSs with diameters range from 50 to 350 μm, provide numerous cell-adhesive interfaces and interconnected macro-pores for enhanced cell adhesion, proliferation and migration. Subcutaneous embedding trials show the in situ swelling aggregation and wet tissue adhesion of ca-CGMSs as well as their capacity in recruiting autologous cells in rat mastectomy models. The trials in rabbit mastectomy models demonstrate that, compared with PFS gluing, the implanted dried ca-CGMSs not only significantly inhibit seroma formation, but also achieve enhanced wound healing by inducing the formation of vascularized neo-tissue. The ca-CGMSs show a great potential to be the next-generation of restorative materials for both preventing seroma formation and healing subcutaneous wounds.http://www.sciencedirect.com/science/article/pii/S2590006424003740Wound healingMicrosphereSeromaCatecholTissue engineeringGelatin |
| spellingShingle | Xinping Wang Guoqing Wang Jianfei Wang Junqiang Xue Gaoli Liu Changjiang Fan Catechol-rich gelatin microspheres as restorative medical implants intended for inhibiting seroma formation and promoting wound healing Materials Today Bio Wound healing Microsphere Seroma Catechol Tissue engineering Gelatin |
| title | Catechol-rich gelatin microspheres as restorative medical implants intended for inhibiting seroma formation and promoting wound healing |
| title_full | Catechol-rich gelatin microspheres as restorative medical implants intended for inhibiting seroma formation and promoting wound healing |
| title_fullStr | Catechol-rich gelatin microspheres as restorative medical implants intended for inhibiting seroma formation and promoting wound healing |
| title_full_unstemmed | Catechol-rich gelatin microspheres as restorative medical implants intended for inhibiting seroma formation and promoting wound healing |
| title_short | Catechol-rich gelatin microspheres as restorative medical implants intended for inhibiting seroma formation and promoting wound healing |
| title_sort | catechol rich gelatin microspheres as restorative medical implants intended for inhibiting seroma formation and promoting wound healing |
| topic | Wound healing Microsphere Seroma Catechol Tissue engineering Gelatin |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424003740 |
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