Shotgun metagenomics analysis of gut microbiota of three indigenous fish species from the Kizil River, Xinjiang

This study investigates the gut microbiota composition and functional adaptations in three indigenous fish species from the Kizil River, Xinjiang: Schizothorax biddulphi (SB), Diptychus maculatus (DM), and Triplophysa yarkandensis (TY), recognizing their ecological significance and the need for cons...

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Main Authors: Jingru Yang, Zhuang Qiang, Dandan Zhang, Huimin Hao, Jie Wei, Hamid Syeda Maira, Weimin Wang, Zhulan Nie
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Microbiology
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Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1617701/full
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author Jingru Yang
Jingru Yang
Jingru Yang
Zhuang Qiang
Zhuang Qiang
Zhuang Qiang
Dandan Zhang
Dandan Zhang
Dandan Zhang
Huimin Hao
Huimin Hao
Huimin Hao
Jie Wei
Jie Wei
Jie Wei
Hamid Syeda Maira
Hamid Syeda Maira
Hamid Syeda Maira
Weimin Wang
Weimin Wang
Zhulan Nie
Zhulan Nie
Zhulan Nie
author_facet Jingru Yang
Jingru Yang
Jingru Yang
Zhuang Qiang
Zhuang Qiang
Zhuang Qiang
Dandan Zhang
Dandan Zhang
Dandan Zhang
Huimin Hao
Huimin Hao
Huimin Hao
Jie Wei
Jie Wei
Jie Wei
Hamid Syeda Maira
Hamid Syeda Maira
Hamid Syeda Maira
Weimin Wang
Weimin Wang
Zhulan Nie
Zhulan Nie
Zhulan Nie
author_sort Jingru Yang
collection DOAJ
description This study investigates the gut microbiota composition and functional adaptations in three indigenous fish species from the Kizil River, Xinjiang: Schizothorax biddulphi (SB), Diptychus maculatus (DM), and Triplophysa yarkandensis (TY), recognizing their ecological significance and the need for conservation insights. Shotgun metagenomics was employed to profile the gut microbiota and functional potential. Taxonomic and functional annotations were analyzed, including identification of dominant taxa, biomarkers (LEfSe), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways for metabolic functions, and Carbohydrate-Active enZymes (CAZy) database annotations. Environmental parameters (crude oil pollution, nitrogen levels, pathogen presence) were assessed, and dietary shifts during overwintering were characterized. Distinct gut microbiota profiles were identified: Proteobacteria, Acinetobacter, and Pseudomonas were dominant overall. Species-specific biomarkers were Micromonospora (DM); Proteobacteria, Firmicutes, Aeromonas, and Bacillus (SB); and Mucoromycota, Vibrio, and Alcanivorax (TY). DM and SB exhibited significantly higher Firmicutes/Bacteroidetes ratios and enhanced nutrient utilization capabilities compared to TY. Key functional pathways included enriched fructose/mannose metabolism (SB) and oxidative phosphorylation (DM). CAZy analysis revealed high CE3 abundance across species, with GT6/GT10 (SB) and PL22 (TY) serving as unique enzymatic biomarkers. Dietary shifts during overwintering occurred: DM and TY transitioned towards herbivory, while SB retained carnivorous tendencies despite increased plant consumption. All species showed reduced immunity, with DM and SB particularly vulnerable to Acinetobacter-related infections. Environmental analysis revealed crude oil pollution, elevated nitrogen levels, and contamination with A. baumannii. TY demonstrated notable salinity adaptability but heightened sensitivity to pollution. Host phylogeny exerted a strong influence on microbiota composition and metabolic functions. The results demonstrate host-specific microbial adaptation driven by phylogeny. The distinct functional profiles (nutrient utilization, key metabolic pathways like fructose/mannose metabolism and oxidative phosphorylation, CAZy enzymes) reflect ecological niche specialization. The observed dietary shifts and reduced winter immunity, compounded by environmental stressors (crude oil, nitrogen, A. baumannii), highlight critical vulnerabilities, especially for DM and SB. TY’s salinity adaptation is counterbalanced by pollution sensitivity. This study provides essential insights for developing targeted conservation strategies and sustainable aquaculture practices for these indigenous species within their natural habitat, emphasizing the need for pollution mitigation.
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spelling doaj-art-2705e288bef34d058a0fa081692d04242025-08-20T03:29:34ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-06-011610.3389/fmicb.2025.16177011617701Shotgun metagenomics analysis of gut microbiota of three indigenous fish species from the Kizil River, XinjiangJingru Yang0Jingru Yang1Jingru Yang2Zhuang Qiang3Zhuang Qiang4Zhuang Qiang5Dandan Zhang6Dandan Zhang7Dandan Zhang8Huimin Hao9Huimin Hao10Huimin Hao11Jie Wei12Jie Wei13Jie Wei14Hamid Syeda Maira15Hamid Syeda Maira16Hamid Syeda Maira17Weimin Wang18Weimin Wang19Zhulan Nie20Zhulan Nie21Zhulan Nie22College of Life Science and Technology, Tarim University, Alar, ChinaState Key Laboratory Breeding Base of Protection and Utilization of Biological Resources in Tarim Basin, Xinjiang Production and Construction Crops and Ministry of Science and Technology, Alar, ChinaTarim Rare Fish Research Center, Alar, ChinaCollege of Life Science and Technology, Tarim University, Alar, ChinaState Key Laboratory Breeding Base of Protection and Utilization of Biological Resources in Tarim Basin, Xinjiang Production and Construction Crops and Ministry of Science and Technology, Alar, ChinaTarim Rare Fish Research Center, Alar, ChinaCollege of Life Science and Technology, Tarim University, Alar, ChinaState Key Laboratory Breeding Base of Protection and Utilization of Biological Resources in Tarim Basin, Xinjiang Production and Construction Crops and Ministry of Science and Technology, Alar, ChinaTarim Rare Fish Research Center, Alar, ChinaCollege of Life Science and Technology, Tarim University, Alar, ChinaState Key Laboratory Breeding Base of Protection and Utilization of Biological Resources in Tarim Basin, Xinjiang Production and Construction Crops and Ministry of Science and Technology, Alar, ChinaTarim Rare Fish Research Center, Alar, ChinaCollege of Life Science and Technology, Tarim University, Alar, ChinaState Key Laboratory Breeding Base of Protection and Utilization of Biological Resources in Tarim Basin, Xinjiang Production and Construction Crops and Ministry of Science and Technology, Alar, ChinaTarim Rare Fish Research Center, Alar, ChinaCollege of Life Science and Technology, Tarim University, Alar, ChinaState Key Laboratory Breeding Base of Protection and Utilization of Biological Resources in Tarim Basin, Xinjiang Production and Construction Crops and Ministry of Science and Technology, Alar, ChinaTarim Rare Fish Research Center, Alar, ChinaCollege of Life Science and Technology, Tarim University, Alar, ChinaCollege of Fisheries, Huazhong Agricultural University, Wuhan, ChinaCollege of Life Science and Technology, Tarim University, Alar, ChinaState Key Laboratory Breeding Base of Protection and Utilization of Biological Resources in Tarim Basin, Xinjiang Production and Construction Crops and Ministry of Science and Technology, Alar, ChinaTarim Rare Fish Research Center, Alar, ChinaThis study investigates the gut microbiota composition and functional adaptations in three indigenous fish species from the Kizil River, Xinjiang: Schizothorax biddulphi (SB), Diptychus maculatus (DM), and Triplophysa yarkandensis (TY), recognizing their ecological significance and the need for conservation insights. Shotgun metagenomics was employed to profile the gut microbiota and functional potential. Taxonomic and functional annotations were analyzed, including identification of dominant taxa, biomarkers (LEfSe), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways for metabolic functions, and Carbohydrate-Active enZymes (CAZy) database annotations. Environmental parameters (crude oil pollution, nitrogen levels, pathogen presence) were assessed, and dietary shifts during overwintering were characterized. Distinct gut microbiota profiles were identified: Proteobacteria, Acinetobacter, and Pseudomonas were dominant overall. Species-specific biomarkers were Micromonospora (DM); Proteobacteria, Firmicutes, Aeromonas, and Bacillus (SB); and Mucoromycota, Vibrio, and Alcanivorax (TY). DM and SB exhibited significantly higher Firmicutes/Bacteroidetes ratios and enhanced nutrient utilization capabilities compared to TY. Key functional pathways included enriched fructose/mannose metabolism (SB) and oxidative phosphorylation (DM). CAZy analysis revealed high CE3 abundance across species, with GT6/GT10 (SB) and PL22 (TY) serving as unique enzymatic biomarkers. Dietary shifts during overwintering occurred: DM and TY transitioned towards herbivory, while SB retained carnivorous tendencies despite increased plant consumption. All species showed reduced immunity, with DM and SB particularly vulnerable to Acinetobacter-related infections. Environmental analysis revealed crude oil pollution, elevated nitrogen levels, and contamination with A. baumannii. TY demonstrated notable salinity adaptability but heightened sensitivity to pollution. Host phylogeny exerted a strong influence on microbiota composition and metabolic functions. The results demonstrate host-specific microbial adaptation driven by phylogeny. The distinct functional profiles (nutrient utilization, key metabolic pathways like fructose/mannose metabolism and oxidative phosphorylation, CAZy enzymes) reflect ecological niche specialization. The observed dietary shifts and reduced winter immunity, compounded by environmental stressors (crude oil, nitrogen, A. baumannii), highlight critical vulnerabilities, especially for DM and SB. TY’s salinity adaptation is counterbalanced by pollution sensitivity. This study provides essential insights for developing targeted conservation strategies and sustainable aquaculture practices for these indigenous species within their natural habitat, emphasizing the need for pollution mitigation.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1617701/fullmetagenomicsSchizothorax biddulphiDiptychus maculatusTriplophysa yarkandensisgut microbiota
spellingShingle Jingru Yang
Jingru Yang
Jingru Yang
Zhuang Qiang
Zhuang Qiang
Zhuang Qiang
Dandan Zhang
Dandan Zhang
Dandan Zhang
Huimin Hao
Huimin Hao
Huimin Hao
Jie Wei
Jie Wei
Jie Wei
Hamid Syeda Maira
Hamid Syeda Maira
Hamid Syeda Maira
Weimin Wang
Weimin Wang
Zhulan Nie
Zhulan Nie
Zhulan Nie
Shotgun metagenomics analysis of gut microbiota of three indigenous fish species from the Kizil River, Xinjiang
Frontiers in Microbiology
metagenomics
Schizothorax biddulphi
Diptychus maculatus
Triplophysa yarkandensis
gut microbiota
title Shotgun metagenomics analysis of gut microbiota of three indigenous fish species from the Kizil River, Xinjiang
title_full Shotgun metagenomics analysis of gut microbiota of three indigenous fish species from the Kizil River, Xinjiang
title_fullStr Shotgun metagenomics analysis of gut microbiota of three indigenous fish species from the Kizil River, Xinjiang
title_full_unstemmed Shotgun metagenomics analysis of gut microbiota of three indigenous fish species from the Kizil River, Xinjiang
title_short Shotgun metagenomics analysis of gut microbiota of three indigenous fish species from the Kizil River, Xinjiang
title_sort shotgun metagenomics analysis of gut microbiota of three indigenous fish species from the kizil river xinjiang
topic metagenomics
Schizothorax biddulphi
Diptychus maculatus
Triplophysa yarkandensis
gut microbiota
url https://www.frontiersin.org/articles/10.3389/fmicb.2025.1617701/full
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