HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia
Cervical cancer is the second most common cause of death from cancer in women worldwide, and the development of new diagnostic, prognostic, and treatment strategies merits special attention. Many efforts have been made to design new drugs and develop immunotherapy and gene therapy strategies to trea...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2013/912780 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548662833577984 |
|---|---|
| author | Oscar Peralta-Zaragoza Jessica Deas Claudia Gómez-Cerón Wendy Argelia García-Suastegui Geny del Socorro Fierros-Zárate Nadia Judith Jacobo-Herrera |
| author_facet | Oscar Peralta-Zaragoza Jessica Deas Claudia Gómez-Cerón Wendy Argelia García-Suastegui Geny del Socorro Fierros-Zárate Nadia Judith Jacobo-Herrera |
| author_sort | Oscar Peralta-Zaragoza |
| collection | DOAJ |
| description | Cervical cancer is the second most common cause of death from cancer in women worldwide, and the development of new diagnostic, prognostic, and treatment strategies merits special attention. Many efforts have been made to design new drugs and develop immunotherapy and gene therapy strategies to treat cervical cancer. HPV genotyping has potentially valuable applications in triage of low-grade abnormal cervical cytology, assessment of prognosis and followup of cervical intraepithelial neoplasia, and in treatment strategies for invasive cervical cancer. It is known that during the development of cervical cancer associated with HPV infection, a cascade of abnormal events is induced, including disruption of cellular cycle control, alteration of gene expression, and deregulation of microRNA expression. Thus, the identification and subsequent functional evaluation of host proteins associated with HPV E6 and E7 oncoproteins may provide useful information in understanding cervical carcinogenesis, identifying cervical cancer molecular markers, and developing specific targeting strategies against tumor cells. Therefore, in this paper, we discuss the main diagnostic methods, management strategies, and followup of HPV-associated cervical lesions and review clinical trials applying gene therapy strategies against the development of cervical cancer. |
| format | Article |
| id | doaj-art-27035842c1184754b8ab75d74fe9c378 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-27035842c1184754b8ab75d74fe9c3782025-02-03T06:13:24ZengWileyObstetrics and Gynecology International1687-95891687-95972013-01-01201310.1155/2013/912780912780HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial NeoplasiaOscar Peralta-Zaragoza0Jessica Deas1Claudia Gómez-Cerón2Wendy Argelia García-Suastegui3Geny del Socorro Fierros-Zárate4Nadia Judith Jacobo-Herrera5Direction of Chronic Infections and Cancer, Research Center in Infection Diseases, National Institute of Public Health, Avenida Universidad 655, Cerrada Los Pinos y Caminera, Colonia Santa María Ahuacatitlán, Cuernavaca, 62100 Morelos, MEX, MexicoDirection of Chronic Infections and Cancer, Research Center in Infection Diseases, National Institute of Public Health, Avenida Universidad 655, Cerrada Los Pinos y Caminera, Colonia Santa María Ahuacatitlán, Cuernavaca, 62100 Morelos, MEX, MexicoDirection of Chronic Infections and Cancer, Research Center in Infection Diseases, National Institute of Public Health, Avenida Universidad 655, Cerrada Los Pinos y Caminera, Colonia Santa María Ahuacatitlán, Cuernavaca, 62100 Morelos, MEX, MexicoDirection of Chronic Infections and Cancer, Research Center in Infection Diseases, National Institute of Public Health, Avenida Universidad 655, Cerrada Los Pinos y Caminera, Colonia Santa María Ahuacatitlán, Cuernavaca, 62100 Morelos, MEX, MexicoDirection of Chronic Infections and Cancer, Research Center in Infection Diseases, National Institute of Public Health, Avenida Universidad 655, Cerrada Los Pinos y Caminera, Colonia Santa María Ahuacatitlán, Cuernavaca, 62100 Morelos, MEX, MexicoNational Institute of Medical Sciences and Nutrition “Salvador Zubirán,” Vasco de Quiroga 15, Tlalpan, 14000 México, DF, MexicoCervical cancer is the second most common cause of death from cancer in women worldwide, and the development of new diagnostic, prognostic, and treatment strategies merits special attention. Many efforts have been made to design new drugs and develop immunotherapy and gene therapy strategies to treat cervical cancer. HPV genotyping has potentially valuable applications in triage of low-grade abnormal cervical cytology, assessment of prognosis and followup of cervical intraepithelial neoplasia, and in treatment strategies for invasive cervical cancer. It is known that during the development of cervical cancer associated with HPV infection, a cascade of abnormal events is induced, including disruption of cellular cycle control, alteration of gene expression, and deregulation of microRNA expression. Thus, the identification and subsequent functional evaluation of host proteins associated with HPV E6 and E7 oncoproteins may provide useful information in understanding cervical carcinogenesis, identifying cervical cancer molecular markers, and developing specific targeting strategies against tumor cells. Therefore, in this paper, we discuss the main diagnostic methods, management strategies, and followup of HPV-associated cervical lesions and review clinical trials applying gene therapy strategies against the development of cervical cancer.http://dx.doi.org/10.1155/2013/912780 |
| spellingShingle | Oscar Peralta-Zaragoza Jessica Deas Claudia Gómez-Cerón Wendy Argelia García-Suastegui Geny del Socorro Fierros-Zárate Nadia Judith Jacobo-Herrera HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia Obstetrics and Gynecology International |
| title | HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia |
| title_full | HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia |
| title_fullStr | HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia |
| title_full_unstemmed | HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia |
| title_short | HPV-Based Screening, Triage, Treatment, and Followup Strategies in the Management of Cervical Intraepithelial Neoplasia |
| title_sort | hpv based screening triage treatment and followup strategies in the management of cervical intraepithelial neoplasia |
| url | http://dx.doi.org/10.1155/2013/912780 |
| work_keys_str_mv | AT oscarperaltazaragoza hpvbasedscreeningtriagetreatmentandfollowupstrategiesinthemanagementofcervicalintraepithelialneoplasia AT jessicadeas hpvbasedscreeningtriagetreatmentandfollowupstrategiesinthemanagementofcervicalintraepithelialneoplasia AT claudiagomezceron hpvbasedscreeningtriagetreatmentandfollowupstrategiesinthemanagementofcervicalintraepithelialneoplasia AT wendyargeliagarciasuastegui hpvbasedscreeningtriagetreatmentandfollowupstrategiesinthemanagementofcervicalintraepithelialneoplasia AT genydelsocorrofierroszarate hpvbasedscreeningtriagetreatmentandfollowupstrategiesinthemanagementofcervicalintraepithelialneoplasia AT nadiajudithjacoboherrera hpvbasedscreeningtriagetreatmentandfollowupstrategiesinthemanagementofcervicalintraepithelialneoplasia |