Undifferentiated/Dedifferentiated Carcinomas of the Endometrium: A Retrospective Clinicopathological Study of a Series of 11 Cases
Introduction Undifferentiated endometrial carcinomas (UDECs) are rare subtypes of endometrial carcinomas with aggressive clinical behavior. Histologically, UDEC exhibits a solid growth pattern and consists of monomorphic, discohesive, small to medium-sized round cells, with absent to mini...
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| author | Reshmi J.S Kedar Deodhar Bharat Rekhi Neha Mittal Rohini Kulkarni Sneha Raj Biswajit Dash Sushmita Rath Seema Gulia Jaya Ghosh Supriya Chopra Prachi Mittal Amita Maheshwari Akshay Baheti Nilesh Sable Sudeep Gupta Santosh Menon |
| author_facet | Reshmi J.S Kedar Deodhar Bharat Rekhi Neha Mittal Rohini Kulkarni Sneha Raj Biswajit Dash Sushmita Rath Seema Gulia Jaya Ghosh Supriya Chopra Prachi Mittal Amita Maheshwari Akshay Baheti Nilesh Sable Sudeep Gupta Santosh Menon |
| author_sort | Reshmi J.S |
| collection | DOAJ |
| description |
Introduction Undifferentiated endometrial carcinomas (UDECs) are rare subtypes of endometrial carcinomas with aggressive clinical behavior. Histologically, UDEC exhibits a solid growth pattern and consists of monomorphic, discohesive, small to medium-sized round cells, with absent to minimal neuroendocrine differentiation. When UDEC is accompanied by a differentiated carcinoma component (usually International Federation of Gynecology and Obstetrics [FIGO] grade 1 or 2), it is termed dedifferentiated endometrial carcinoma (DDEC). The diagnosis of these tumors is challenging because of their close histological similarity to grade 3 endometrioid adenocarcinomas. |
| format | Article |
| id | doaj-art-26fea96c9a384d559c8952cf6266efd3 |
| institution | Kabale University |
| issn | 0971-5851 0975-2129 |
| language | English |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-26fea96c9a384d559c8952cf6266efd32025-08-20T03:44:39ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-212910.1055/s-0045-1808062Undifferentiated/Dedifferentiated Carcinomas of the Endometrium: A Retrospective Clinicopathological Study of a Series of 11 CasesReshmi J.S0https://orcid.org/0009-0000-6518-6772Kedar Deodhar1Bharat Rekhi2https://orcid.org/0000-0002-3509-4794Neha Mittal3Rohini Kulkarni4https://orcid.org/0000-0002-4466-1703Sneha Raj5Biswajit Dash6Sushmita Rath7Seema Gulia8Jaya Ghosh9Supriya Chopra10Prachi Mittal11https://orcid.org/0000-0003-3232-6139Amita Maheshwari12Akshay Baheti13https://orcid.org/0000-0002-5376-6750Nilesh Sable14Sudeep Gupta15Santosh Menon16https://orcid.org/0000-0002-4140-0671Department of Pathology, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Pathology, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Pathology, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Pathology, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Gynecologic Oncology, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Gynecologic Oncology, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Gynecologic Oncology, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Medical Oncology, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Medical Oncology, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Medical Oncology, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Radiation Oncology, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Radiation Oncology, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Gynecologic Oncology, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Radiodiagnosis, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Radiodiagnosis, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Medical Oncology, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, IndiaDepartment of Pathology, Tata Memorial Centre and Homi Bhabha National Institute, Mumbai, Maharashtra, India Introduction Undifferentiated endometrial carcinomas (UDECs) are rare subtypes of endometrial carcinomas with aggressive clinical behavior. Histologically, UDEC exhibits a solid growth pattern and consists of monomorphic, discohesive, small to medium-sized round cells, with absent to minimal neuroendocrine differentiation. When UDEC is accompanied by a differentiated carcinoma component (usually International Federation of Gynecology and Obstetrics [FIGO] grade 1 or 2), it is termed dedifferentiated endometrial carcinoma (DDEC). The diagnosis of these tumors is challenging because of their close histological similarity to grade 3 endometrioid adenocarcinomas.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1808062undifferentiateddedifferentiatedendometriummismatch repair |
| spellingShingle | Reshmi J.S Kedar Deodhar Bharat Rekhi Neha Mittal Rohini Kulkarni Sneha Raj Biswajit Dash Sushmita Rath Seema Gulia Jaya Ghosh Supriya Chopra Prachi Mittal Amita Maheshwari Akshay Baheti Nilesh Sable Sudeep Gupta Santosh Menon Undifferentiated/Dedifferentiated Carcinomas of the Endometrium: A Retrospective Clinicopathological Study of a Series of 11 Cases Indian Journal of Medical and Paediatric Oncology undifferentiated dedifferentiated endometrium mismatch repair |
| title | Undifferentiated/Dedifferentiated Carcinomas of the Endometrium: A Retrospective Clinicopathological Study of a Series of 11 Cases |
| title_full | Undifferentiated/Dedifferentiated Carcinomas of the Endometrium: A Retrospective Clinicopathological Study of a Series of 11 Cases |
| title_fullStr | Undifferentiated/Dedifferentiated Carcinomas of the Endometrium: A Retrospective Clinicopathological Study of a Series of 11 Cases |
| title_full_unstemmed | Undifferentiated/Dedifferentiated Carcinomas of the Endometrium: A Retrospective Clinicopathological Study of a Series of 11 Cases |
| title_short | Undifferentiated/Dedifferentiated Carcinomas of the Endometrium: A Retrospective Clinicopathological Study of a Series of 11 Cases |
| title_sort | undifferentiated dedifferentiated carcinomas of the endometrium a retrospective clinicopathological study of a series of 11 cases |
| topic | undifferentiated dedifferentiated endometrium mismatch repair |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1808062 |
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