Undifferentiated/Dedifferentiated Carcinomas of the Endometrium: A Retrospective Clinicopathological Study of a Series of 11 Cases

Undifferentiated/Dedifferentiated Carcinomas of the Endometrium: A Retrospective Clinicopathological Study of a Series of 11 Cases

Introduction Undifferentiated endometrial carcinomas (UDECs) are rare subtypes of endometrial carcinomas with aggressive clinical behavior. Histologically, UDEC exhibits a solid growth pattern and consists of monomorphic, discohesive, small to medium-sized round cells, with absent to mini...

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Main Authors: Reshmi J.S, Kedar Deodhar, Bharat Rekhi, Neha Mittal, Rohini Kulkarni, Sneha Raj, Biswajit Dash, Sushmita Rath, Seema Gulia, Jaya Ghosh, Supriya Chopra, Prachi Mittal, Amita Maheshwari, Akshay Baheti, Nilesh Sable, Sudeep Gupta, Santosh Menon
Format: Article
Language:English
Published: Thieme Medical and Scientific Publishers Pvt. Ltd.
Series:Indian Journal of Medical and Paediatric Oncology
Subjects:
undifferentiated
dedifferentiated
endometrium
mismatch repair
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0045-1808062
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Summary:Introduction Undifferentiated endometrial carcinomas (UDECs) are rare subtypes of endometrial carcinomas with aggressive clinical behavior. Histologically, UDEC exhibits a solid growth pattern and consists of monomorphic, discohesive, small to medium-sized round cells, with absent to minimal neuroendocrine differentiation. When UDEC is accompanied by a differentiated carcinoma component (usually International Federation of Gynecology and Obstetrics [FIGO] grade 1 or 2), it is termed dedifferentiated endometrial carcinoma (DDEC). The diagnosis of these tumors is challenging because of their close histological similarity to grade 3 endometrioid adenocarcinomas.
ISSN:0971-5851
0975-2129

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