Cost-of-illness of gastroenteritis caused by rotavirus in Chinese children less than 5 years
Acute gastroenteritis (AGE) caused by rotavirus (RV) remains a public health issue in China. To accelerate the mass rotavirus vaccination, it is important to inform the policy maker, and the public of the economic burden caused by rotavirus infection. A meta-analysis was conducted applying standardi...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2023.2276619 |
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| author | Xiao-Li Fu Yan Ma Zheng Li Yang-Yang Qi Si-Jie Wang Li-Jun Fu Song-Mei Wang Lorenz von Seidlein Xuan-Yi Wang |
| author_facet | Xiao-Li Fu Yan Ma Zheng Li Yang-Yang Qi Si-Jie Wang Li-Jun Fu Song-Mei Wang Lorenz von Seidlein Xuan-Yi Wang |
| author_sort | Xiao-Li Fu |
| collection | DOAJ |
| description | Acute gastroenteritis (AGE) caused by rotavirus (RV) remains a public health issue in China. To accelerate the mass rotavirus vaccination, it is important to inform the policy maker, and the public of the economic burden caused by rotavirus infection. A meta-analysis was conducted applying standardized algorithms. Articles published before January 1, 2023, in English and Chinese were searched through PubMed, CNKI, and WanFang Data. Studies with cost analysis of RV AGE were included. A random-effects model was applied to synthesize the total cost of RV AGE from the societal perspective. A prospective survey aimed to measure the cost of RV AGE was conducted in 2021 and 2022 in Shaoxing city, Zhejiang province, that can represent the developed region. The cost data was applied as deviation indicator, in comparison with the pooled estimate generated from meta-analysis. Totally 286 articles were identified, and eventually 12 studies were included. The pooled total social cost of RV AGE was US$282.1 (95%CI: US$213.4–350.7). The pooled private cost of RV AGE was US$206.4 (95%CI: US$155.2–257.5). RV AGE hospitalized and RV AGE incurred in developed regions caused remarkable higher burden (US$631.2 [95%CI: US$512.6–749.8], and US$333.6 [95%CI: US$234.1–433.2] respectively), compared to RV AGE treated at outpatient, and incurred in less developed regions. Our study demonstrates that RV AGE causes a significant economic burden in China. Given the promising effectiveness and highly cost-effective, introduction of rotavirus vaccines in national immunization programs could substantially reduce the economic burden in China. |
| format | Article |
| id | doaj-art-26fea65babb24abd862101fab2de23bf |
| institution | Kabale University |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-26fea65babb24abd862101fab2de23bf2025-08-20T03:26:39ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2023-12-0119310.1080/21645515.2023.2276619Cost-of-illness of gastroenteritis caused by rotavirus in Chinese children less than 5 yearsXiao-Li Fu0Yan Ma1Zheng Li2Yang-Yang Qi3Si-Jie Wang4Li-Jun Fu5Song-Mei Wang6Lorenz von Seidlein7Xuan-Yi Wang8Key Laboratory of Medical Molecular Virology of MoE & MoH,Institutes of Biomedical Sciences, Fudan University, Shanghai, ChinaDepartment of Infectious Disease Prevention and Control, Shaoxing Center for Disease Control and Prevention, Shaoxing, ChinaShanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, ChinaShanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, ChinaKey Laboratory of Medical Molecular Virology of MoE & MoH,Institutes of Biomedical Sciences, Fudan University, Shanghai, ChinaDepartment of Infectious Disease Prevention and Control, Shaoxing Center for Disease Control and Prevention, Shaoxing, ChinaLaboratory of Molecular Biology, Training Center of Medical Experiments, School of Basic Medical Sciences, Fudan University, Shanghai, ChinaMahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, ThailandKey Laboratory of Medical Molecular Virology of MoE & MoH,Institutes of Biomedical Sciences, Fudan University, Shanghai, ChinaAcute gastroenteritis (AGE) caused by rotavirus (RV) remains a public health issue in China. To accelerate the mass rotavirus vaccination, it is important to inform the policy maker, and the public of the economic burden caused by rotavirus infection. A meta-analysis was conducted applying standardized algorithms. Articles published before January 1, 2023, in English and Chinese were searched through PubMed, CNKI, and WanFang Data. Studies with cost analysis of RV AGE were included. A random-effects model was applied to synthesize the total cost of RV AGE from the societal perspective. A prospective survey aimed to measure the cost of RV AGE was conducted in 2021 and 2022 in Shaoxing city, Zhejiang province, that can represent the developed region. The cost data was applied as deviation indicator, in comparison with the pooled estimate generated from meta-analysis. Totally 286 articles were identified, and eventually 12 studies were included. The pooled total social cost of RV AGE was US$282.1 (95%CI: US$213.4–350.7). The pooled private cost of RV AGE was US$206.4 (95%CI: US$155.2–257.5). RV AGE hospitalized and RV AGE incurred in developed regions caused remarkable higher burden (US$631.2 [95%CI: US$512.6–749.8], and US$333.6 [95%CI: US$234.1–433.2] respectively), compared to RV AGE treated at outpatient, and incurred in less developed regions. Our study demonstrates that RV AGE causes a significant economic burden in China. Given the promising effectiveness and highly cost-effective, introduction of rotavirus vaccines in national immunization programs could substantially reduce the economic burden in China.https://www.tandfonline.com/doi/10.1080/21645515.2023.2276619Rotavirusacute gastroenteritiseconomic burdenChina |
| spellingShingle | Xiao-Li Fu Yan Ma Zheng Li Yang-Yang Qi Si-Jie Wang Li-Jun Fu Song-Mei Wang Lorenz von Seidlein Xuan-Yi Wang Cost-of-illness of gastroenteritis caused by rotavirus in Chinese children less than 5 years Human Vaccines & Immunotherapeutics Rotavirus acute gastroenteritis economic burden China |
| title | Cost-of-illness of gastroenteritis caused by rotavirus in Chinese children less than 5 years |
| title_full | Cost-of-illness of gastroenteritis caused by rotavirus in Chinese children less than 5 years |
| title_fullStr | Cost-of-illness of gastroenteritis caused by rotavirus in Chinese children less than 5 years |
| title_full_unstemmed | Cost-of-illness of gastroenteritis caused by rotavirus in Chinese children less than 5 years |
| title_short | Cost-of-illness of gastroenteritis caused by rotavirus in Chinese children less than 5 years |
| title_sort | cost of illness of gastroenteritis caused by rotavirus in chinese children less than 5 years |
| topic | Rotavirus acute gastroenteritis economic burden China |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2023.2276619 |
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