Does C reactive protein/Albumin ratio have prognostic value in patients with COVID-19
Introduction: There is paucity of data regarding C reactive protein/Albumin (CRP/Alb) ratio in patients with SARS-CoV-2 infection. We aimed to evaluate the significance of CRP/Alb ratio in COVID-19 patients. Methodology: Patients hospitalized between March – April 2020 with COVID-19, who had CRP...
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The Journal of Infection in Developing Countries
2021-08-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/14826 |
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| author | Aleksandr Kalabin Vishnu R Mani Sebastian C Valdivieso Brian Donaldson |
| author_facet | Aleksandr Kalabin Vishnu R Mani Sebastian C Valdivieso Brian Donaldson |
| author_sort | Aleksandr Kalabin |
| collection | DOAJ |
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Introduction: There is paucity of data regarding C reactive protein/Albumin (CRP/Alb) ratio in patients with SARS-CoV-2 infection. We aimed to evaluate the significance of CRP/Alb ratio in COVID-19 patients.
Methodology: Patients hospitalized between March – April 2020 with COVID-19, who had CRP and Albumin levels documented within 24 hours from admission were retrospectively analyzed. Unpaired Student’s t-test was used for continuous and Pearson Chi-square (χ²) test for categorical variables. Univariate and multivariate logistic regression models were developed to assess the relationship between CRP/Alb and mortality. Nonparametric correlations were calculated using Spearman’s Rho correlation coefficient.
Results: 75 patients were included. Mean age was 62.92, 26 females (34.67%) and 49 males (65.33%), mean Body Mass Index (BMI) 29.86, mean body temperature 101.3 and mean length of stay (LOS) was 14.80 days. 24 (32%) patients required invasive mechanical ventilation and 51 (68%) did not, mean CRP/Alb ratio was 6.89 and 4.7 respectively (p = 0.036). 15 (20%) patients died, 60 (80%) survived and the mean CRP/Alb difference between these groups was also statistically significant (7.74 vs 4.83, p = 0.02). LOS (OR 0.71, 95% CI 0.57.-0.88, p < 0.001) and BUN (OR 1.04, 95% CI 1.01.-1.07, p = 0.006) were independent predictors of mortality by multivariate logistic regression, whereas CRP/Alb (OR 1.21, 95% CI 0.96.-1.51, p = 0.06) was not.
Conclusions: CRP/Alb ratio could be useful as a prognostic indicator of disease severity in COVID-19, but we could not corroborate its potential to predict mortality. The work was conducted at Columbia University College of Physicians and Surgeons at Harlem Hospital.
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| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-26fc46c897944a3a8eef22b7b77fcbee2025-08-20T02:27:14ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802021-08-01150810.3855/jidc.14826Does C reactive protein/Albumin ratio have prognostic value in patients with COVID-19Aleksandr Kalabin0Vishnu R Mani1Sebastian C Valdivieso2Brian Donaldson3Columbia University College of Physicians and Surgeons at Harlem Hospital, New York City, NY, United StatesColumbia University College of Physicians and Surgeons at Harlem Hospital, New York City, NY, United StatesColumbia University College of Physicians and Surgeons at Harlem Hospital, New York City, NY, United StatesColumbia University College of Physicians and Surgeons at Harlem Hospital, New York City, NY, United States Introduction: There is paucity of data regarding C reactive protein/Albumin (CRP/Alb) ratio in patients with SARS-CoV-2 infection. We aimed to evaluate the significance of CRP/Alb ratio in COVID-19 patients. Methodology: Patients hospitalized between March – April 2020 with COVID-19, who had CRP and Albumin levels documented within 24 hours from admission were retrospectively analyzed. Unpaired Student’s t-test was used for continuous and Pearson Chi-square (χ²) test for categorical variables. Univariate and multivariate logistic regression models were developed to assess the relationship between CRP/Alb and mortality. Nonparametric correlations were calculated using Spearman’s Rho correlation coefficient. Results: 75 patients were included. Mean age was 62.92, 26 females (34.67%) and 49 males (65.33%), mean Body Mass Index (BMI) 29.86, mean body temperature 101.3 and mean length of stay (LOS) was 14.80 days. 24 (32%) patients required invasive mechanical ventilation and 51 (68%) did not, mean CRP/Alb ratio was 6.89 and 4.7 respectively (p = 0.036). 15 (20%) patients died, 60 (80%) survived and the mean CRP/Alb difference between these groups was also statistically significant (7.74 vs 4.83, p = 0.02). LOS (OR 0.71, 95% CI 0.57.-0.88, p < 0.001) and BUN (OR 1.04, 95% CI 1.01.-1.07, p = 0.006) were independent predictors of mortality by multivariate logistic regression, whereas CRP/Alb (OR 1.21, 95% CI 0.96.-1.51, p = 0.06) was not. Conclusions: CRP/Alb ratio could be useful as a prognostic indicator of disease severity in COVID-19, but we could not corroborate its potential to predict mortality. The work was conducted at Columbia University College of Physicians and Surgeons at Harlem Hospital. https://jidc.org/index.php/journal/article/view/14826SARS-CoV-2COVID-19C reactive protein/Albumin ratiopandemic |
| spellingShingle | Aleksandr Kalabin Vishnu R Mani Sebastian C Valdivieso Brian Donaldson Does C reactive protein/Albumin ratio have prognostic value in patients with COVID-19 Journal of Infection in Developing Countries SARS-CoV-2 COVID-19 C reactive protein/Albumin ratio pandemic |
| title | Does C reactive protein/Albumin ratio have prognostic value in patients with COVID-19 |
| title_full | Does C reactive protein/Albumin ratio have prognostic value in patients with COVID-19 |
| title_fullStr | Does C reactive protein/Albumin ratio have prognostic value in patients with COVID-19 |
| title_full_unstemmed | Does C reactive protein/Albumin ratio have prognostic value in patients with COVID-19 |
| title_short | Does C reactive protein/Albumin ratio have prognostic value in patients with COVID-19 |
| title_sort | does c reactive protein albumin ratio have prognostic value in patients with covid 19 |
| topic | SARS-CoV-2 COVID-19 C reactive protein/Albumin ratio pandemic |
| url | https://jidc.org/index.php/journal/article/view/14826 |
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