Insights into regulatory T-cell and type-I interferon roles in determining abacavir-induced hypersensitivity or immune tolerance

Insights into regulatory T-cell and type-I interferon roles in determining abacavir-induced hypersensitivity or immune tolerance

IntroductionClinical use of several small molecule drugs may lead to severe T-cell-mediated idiosyncratic drug hypersensitivity reactions (iDHR) linked to HLA alleles, including abacavir (ABC) with HLA-B*57:01. Due to study limitations in humans, pathogenic networks in iDHR remain elusive. HLA trans...

Full description

Saved in:
Bibliographic Details
Main Authors: Marco Cardone, Hratch M. Baghdassarian, Maryam Khalaj, Kirthiram Krishnaveni Sivakumar, SuJin Hwang, Sintayehu Gebreyohannes, Kazuyo Takeda, Yura Jang, Nathan E. Lewis, Michael A. Norcross, Montserrat Puig
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
drug hypersensitivity reactions
abacavir
Treg
type-I IFN
T-cell
HLA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1612451/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items