TGF-β receptor-specific NanoBRET Target Engagement in living cells for high-throughput kinase inhibitor screens

TGF-β receptor-specific NanoBRET Target Engagement in living cells for high-throughput kinase inhibitor screens

Targeting transforming growth factor-β (TGF-β) receptors is a promising pharmacological approach to normalize aberrant signaling in genetic and non-genetic TGF-β associated diseases including fibrosis, cancer, cardiovascular and musculoskeletal disorders. To identify novel TGF-β receptor kinase inhi...

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Bibliographic Details
Main Authors: Marius Wits, Nicole Haarmans, Gonzalo Sanchez-Duffhues, Marie-José Goumans
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:SLAS Discovery
Subjects:
BMP
Drug development
Rare disease
Cancer
Angiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555224000583
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