Diagnostic value of Tc-99m-MIBI SPECT/CT in parathyroid carcinoma with lung metastasis: a case report and literature review
PurposeParathyroid carcinoma (PC) is an extremely rare disease, typically presenting with marked elevations of serum calcium concentrations and associated with significantly increased parathyroid hormone (PTH) levels. Although it progresses slowly, approximately25% of PC patients have lung metastase...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1501447/full |
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| author | Yirong Zhu Yirong Zhu Lian Wang Jiaxi You Shengming Deng Yizhen Shi Zengli Liu Zhihui Hong Zhihui Hong Zhihui Hong Zhihui Hong |
| author_facet | Yirong Zhu Yirong Zhu Lian Wang Jiaxi You Shengming Deng Yizhen Shi Zengli Liu Zhihui Hong Zhihui Hong Zhihui Hong Zhihui Hong |
| author_sort | Yirong Zhu |
| collection | DOAJ |
| description | PurposeParathyroid carcinoma (PC) is an extremely rare disease, typically presenting with marked elevations of serum calcium concentrations and associated with significantly increased parathyroid hormone (PTH) levels. Although it progresses slowly, approximately25% of PC patients have lung metastases. In the present study, we aimed to evaluate the role of technetium-99m methoxy isobutyl isonitrile (Tc-99m-MIBI; sestamibi) SPECT/CT scintigraphy in the preoperative localization of parathyroid adenomas, incidental metastases findings of PC, and ectopic parathyroid tissue.MethodsWe presented a rare case alongside a review of the relevant literature.ResultsWe described an unusual case of a 25-year-old female patient with co-occurrence of PC and lung metastasis. The primary PC lesion showed no radioactive uptake, while the lung metastasis presented as a hyperfunctioning nodule, successfully localized using Tc-99m-MIBI SPECT/CT and confirmed through surgical and pathological examination.ConclusionsThis case emphasized the uniqueness of Tc-99m-MIBI SPECT/CT imaging in diagnosing PC and metastatic lesions. The appropriate application of this technique may help avert the aggressive clinical progression of PC. |
| format | Article |
| id | doaj-art-26f9f2e77d384d9fb682fd885c37d815 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-26f9f2e77d384d9fb682fd885c37d8152025-08-20T02:40:32ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-12-011410.3389/fonc.2024.15014471501447Diagnostic value of Tc-99m-MIBI SPECT/CT in parathyroid carcinoma with lung metastasis: a case report and literature reviewYirong Zhu0Yirong Zhu1Lian Wang2Jiaxi You3Shengming Deng4Yizhen Shi5Zengli Liu6Zhihui Hong7Zhihui Hong8Zhihui Hong9Zhihui Hong10Department of Nuclear Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaShanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, ChinaDepartment of Oncology, Xuyi People’s Hospital, Xuyi, ChinaDepartment of Nuclear Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Nuclear Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Nuclear Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Nuclear Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaShanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, ChinaState Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, ChinaNational Health Commission (NHC) Key Laboratory of Nuclear Medicine and Jiangsu Key Laboratory of Molecular Nuclear Medicine, Wuxi, ChinaPurposeParathyroid carcinoma (PC) is an extremely rare disease, typically presenting with marked elevations of serum calcium concentrations and associated with significantly increased parathyroid hormone (PTH) levels. Although it progresses slowly, approximately25% of PC patients have lung metastases. In the present study, we aimed to evaluate the role of technetium-99m methoxy isobutyl isonitrile (Tc-99m-MIBI; sestamibi) SPECT/CT scintigraphy in the preoperative localization of parathyroid adenomas, incidental metastases findings of PC, and ectopic parathyroid tissue.MethodsWe presented a rare case alongside a review of the relevant literature.ResultsWe described an unusual case of a 25-year-old female patient with co-occurrence of PC and lung metastasis. The primary PC lesion showed no radioactive uptake, while the lung metastasis presented as a hyperfunctioning nodule, successfully localized using Tc-99m-MIBI SPECT/CT and confirmed through surgical and pathological examination.ConclusionsThis case emphasized the uniqueness of Tc-99m-MIBI SPECT/CT imaging in diagnosing PC and metastatic lesions. The appropriate application of this technique may help avert the aggressive clinical progression of PC.https://www.frontiersin.org/articles/10.3389/fonc.2024.1501447/fullparathyroid carcinomalung metastasisPTHTc-99m-MIBI SPECT/CTdiagnosiscase report |
| spellingShingle | Yirong Zhu Yirong Zhu Lian Wang Jiaxi You Shengming Deng Yizhen Shi Zengli Liu Zhihui Hong Zhihui Hong Zhihui Hong Zhihui Hong Diagnostic value of Tc-99m-MIBI SPECT/CT in parathyroid carcinoma with lung metastasis: a case report and literature review Frontiers in Oncology parathyroid carcinoma lung metastasis PTH Tc-99m-MIBI SPECT/CT diagnosis case report |
| title | Diagnostic value of Tc-99m-MIBI SPECT/CT in parathyroid carcinoma with lung metastasis: a case report and literature review |
| title_full | Diagnostic value of Tc-99m-MIBI SPECT/CT in parathyroid carcinoma with lung metastasis: a case report and literature review |
| title_fullStr | Diagnostic value of Tc-99m-MIBI SPECT/CT in parathyroid carcinoma with lung metastasis: a case report and literature review |
| title_full_unstemmed | Diagnostic value of Tc-99m-MIBI SPECT/CT in parathyroid carcinoma with lung metastasis: a case report and literature review |
| title_short | Diagnostic value of Tc-99m-MIBI SPECT/CT in parathyroid carcinoma with lung metastasis: a case report and literature review |
| title_sort | diagnostic value of tc 99m mibi spect ct in parathyroid carcinoma with lung metastasis a case report and literature review |
| topic | parathyroid carcinoma lung metastasis PTH Tc-99m-MIBI SPECT/CT diagnosis case report |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1501447/full |
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