Uniform Suspension of the Clustered Triamcinolone Acetonide Particle
Purpose. MaQaid (MaQ) is a new triamcinolone acetonide commercialised in Japan to visualize the vitreous. Because MaQ is preservative-free, it has a lower risk of ocular toxicities. However, since MaQ is only available as a powder, it needs suspenssion. Suspension does not always result uniformally,...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2013/315658 |
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| _version_ | 1849307244931317760 |
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| author | Masahiko Sugimoto Mineo Kondo Masayuki Horiguchi |
| author_facet | Masahiko Sugimoto Mineo Kondo Masayuki Horiguchi |
| author_sort | Masahiko Sugimoto |
| collection | DOAJ |
| description | Purpose. MaQaid (MaQ) is a new triamcinolone acetonide commercialised in Japan to visualize the vitreous. Because MaQ is preservative-free, it has a lower risk of ocular toxicities. However, since MaQ is only available as a powder, it needs suspenssion. Suspension does not always result uniformally, which causes poor visibility. This study reports a new MaQ suspension for better visibility. Methods. After medium addition to a MaQ vial, various methods were used. These included the use of (1) vortex mixer, (2) two syringes and a three-way stopcock, and (3) ultrasonic washer. We calculated suspended MaQ concentration (). To evaluate the reproducibility, we estimated the coefficient of variance (CV, ). We used this MaQ for pig eyes, and vitreous visualization was simulated. Subsequently, we used this MaQ suspension for humans.
Results.
MaQ suspensions were sucessfull, and the concentrations of single particles increased significantly (). The CV was 36.1% for the routine method and 9.03% ffor the new method. Administration of a suspended MaQ made it possible to clearly visualize the vitreous in both pig and human eyes. Conclusions.
We devised new techniques for uniformal MaQ suspension. These new methods can compensate for the MaQ disadvantages and ensure a safety surgery. |
| format | Article |
| id | doaj-art-26f4ec9b5b044c06a23e1bdcfd1ee0fd |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-26f4ec9b5b044c06a23e1bdcfd1ee0fd2025-08-20T03:54:48ZengWileyJournal of Ophthalmology2090-004X2090-00582013-01-01201310.1155/2013/315658315658Uniform Suspension of the Clustered Triamcinolone Acetonide ParticleMasahiko Sugimoto0Mineo Kondo1Masayuki Horiguchi2Department of Ophthalmology, Mie University, School of Medicine, 2-174 Edobashi, Mie, Tsu 514-8507, JapanDepartment of Ophthalmology, Mie University, School of Medicine, 2-174 Edobashi, Mie, Tsu 514-8507, JapanDepartment of Ophthalmology, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi. 470-1192, JapanPurpose. MaQaid (MaQ) is a new triamcinolone acetonide commercialised in Japan to visualize the vitreous. Because MaQ is preservative-free, it has a lower risk of ocular toxicities. However, since MaQ is only available as a powder, it needs suspenssion. Suspension does not always result uniformally, which causes poor visibility. This study reports a new MaQ suspension for better visibility. Methods. After medium addition to a MaQ vial, various methods were used. These included the use of (1) vortex mixer, (2) two syringes and a three-way stopcock, and (3) ultrasonic washer. We calculated suspended MaQ concentration (). To evaluate the reproducibility, we estimated the coefficient of variance (CV, ). We used this MaQ for pig eyes, and vitreous visualization was simulated. Subsequently, we used this MaQ suspension for humans. Results. MaQ suspensions were sucessfull, and the concentrations of single particles increased significantly (). The CV was 36.1% for the routine method and 9.03% ffor the new method. Administration of a suspended MaQ made it possible to clearly visualize the vitreous in both pig and human eyes. Conclusions. We devised new techniques for uniformal MaQ suspension. These new methods can compensate for the MaQ disadvantages and ensure a safety surgery.http://dx.doi.org/10.1155/2013/315658 |
| spellingShingle | Masahiko Sugimoto Mineo Kondo Masayuki Horiguchi Uniform Suspension of the Clustered Triamcinolone Acetonide Particle Journal of Ophthalmology |
| title | Uniform Suspension of the Clustered Triamcinolone Acetonide Particle |
| title_full | Uniform Suspension of the Clustered Triamcinolone Acetonide Particle |
| title_fullStr | Uniform Suspension of the Clustered Triamcinolone Acetonide Particle |
| title_full_unstemmed | Uniform Suspension of the Clustered Triamcinolone Acetonide Particle |
| title_short | Uniform Suspension of the Clustered Triamcinolone Acetonide Particle |
| title_sort | uniform suspension of the clustered triamcinolone acetonide particle |
| url | http://dx.doi.org/10.1155/2013/315658 |
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