Genipin Cross-Linked Polymeric Alginate-Chitosan Microcapsules for Oral Delivery: In-Vitro Analysis
We have previously reported the preparation of the genipin cross-linked alginate-chitosan (GCAC) microcapsules composed of an alginate core with a genipin cross-linked chitosan membrane. This paper is the further investigation on their structural and physical characteristics. Results showed that the...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2009/617184 |
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| author | Hongmei Chen Wei Ouyang Christopher Martoni Satya Prakash |
| author_facet | Hongmei Chen Wei Ouyang Christopher Martoni Satya Prakash |
| author_sort | Hongmei Chen |
| collection | DOAJ |
| description | We have previously reported the preparation of the genipin cross-linked alginate-chitosan (GCAC) microcapsules composed of an alginate core with a genipin cross-linked chitosan membrane. This paper is the further investigation on their structural and physical characteristics. Results showed that the GCAC microcapsules had a smooth and dense surface and a networked interior. Cross-linking by genipin substantially reduced swelling and physical disintegration of microcapsules induced by nongelling ions and calcium sequestrants. Strong resistance to mechanical shear forces and enzymatic degradation was observed. Furthermore, the GCAC membranes were permeable to bovine serum albumin and maintained a molecular weight cutoff at 70 KD, analogous to the widely studied alginate-chitosan, and alginate-poly-L-lysine-alginate microcapsules. The release features and the tolerance of the GCAC microcapsules in the stimulated gastrointestinal environment were also investigated. This GCAC microcapsule formulation offers significant potential as a delivery vehicle for many biomedical applications. |
| format | Article |
| id | doaj-art-26ef2cd5d8f94a339a141e876356bcee |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-26ef2cd5d8f94a339a141e876356bcee2025-02-03T05:46:23ZengWileyInternational Journal of Polymer Science1687-94221687-94302009-01-01200910.1155/2009/617184617184Genipin Cross-Linked Polymeric Alginate-Chitosan Microcapsules for Oral Delivery: In-Vitro AnalysisHongmei Chen0Wei Ouyang1Christopher Martoni2Satya Prakash3Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Physiology, Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, QC, H3A 2B4, CanadaBiomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Physiology, Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, QC, H3A 2B4, CanadaBiomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Physiology, Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, QC, H3A 2B4, CanadaBiomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Physiology, Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, QC, H3A 2B4, CanadaWe have previously reported the preparation of the genipin cross-linked alginate-chitosan (GCAC) microcapsules composed of an alginate core with a genipin cross-linked chitosan membrane. This paper is the further investigation on their structural and physical characteristics. Results showed that the GCAC microcapsules had a smooth and dense surface and a networked interior. Cross-linking by genipin substantially reduced swelling and physical disintegration of microcapsules induced by nongelling ions and calcium sequestrants. Strong resistance to mechanical shear forces and enzymatic degradation was observed. Furthermore, the GCAC membranes were permeable to bovine serum albumin and maintained a molecular weight cutoff at 70 KD, analogous to the widely studied alginate-chitosan, and alginate-poly-L-lysine-alginate microcapsules. The release features and the tolerance of the GCAC microcapsules in the stimulated gastrointestinal environment were also investigated. This GCAC microcapsule formulation offers significant potential as a delivery vehicle for many biomedical applications.http://dx.doi.org/10.1155/2009/617184 |
| spellingShingle | Hongmei Chen Wei Ouyang Christopher Martoni Satya Prakash Genipin Cross-Linked Polymeric Alginate-Chitosan Microcapsules for Oral Delivery: In-Vitro Analysis International Journal of Polymer Science |
| title | Genipin Cross-Linked Polymeric Alginate-Chitosan Microcapsules for Oral Delivery: In-Vitro Analysis |
| title_full | Genipin Cross-Linked Polymeric Alginate-Chitosan Microcapsules for Oral Delivery: In-Vitro Analysis |
| title_fullStr | Genipin Cross-Linked Polymeric Alginate-Chitosan Microcapsules for Oral Delivery: In-Vitro Analysis |
| title_full_unstemmed | Genipin Cross-Linked Polymeric Alginate-Chitosan Microcapsules for Oral Delivery: In-Vitro Analysis |
| title_short | Genipin Cross-Linked Polymeric Alginate-Chitosan Microcapsules for Oral Delivery: In-Vitro Analysis |
| title_sort | genipin cross linked polymeric alginate chitosan microcapsules for oral delivery in vitro analysis |
| url | http://dx.doi.org/10.1155/2009/617184 |
| work_keys_str_mv | AT hongmeichen genipincrosslinkedpolymericalginatechitosanmicrocapsulesfororaldeliveryinvitroanalysis AT weiouyang genipincrosslinkedpolymericalginatechitosanmicrocapsulesfororaldeliveryinvitroanalysis AT christophermartoni genipincrosslinkedpolymericalginatechitosanmicrocapsulesfororaldeliveryinvitroanalysis AT satyaprakash genipincrosslinkedpolymericalginatechitosanmicrocapsulesfororaldeliveryinvitroanalysis |