A Rare Cause of Thrombotic Thrombocytopenia Purpura- (TTP-) Like Syndrome, Vitamin B12 Deficiency: Interpretation of Significant Pathological Findings
Thrombotic thrombocytopenia purpura (TTP) is a hematological emergency that requires rapid assessment followed by prompt initiation of therapy due to high mortality associated with delayed treatment. TTP has many causes including heritable syndromes, ADAMTS13 deficiency, and drugs-related etiologies...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/1529306 |
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| author | Morgan Bailey Travis Maestas Robert Betancourt Dalia Mikhael Hani M. Babiker |
| author_facet | Morgan Bailey Travis Maestas Robert Betancourt Dalia Mikhael Hani M. Babiker |
| author_sort | Morgan Bailey |
| collection | DOAJ |
| description | Thrombotic thrombocytopenia purpura (TTP) is a hematological emergency that requires rapid assessment followed by prompt initiation of therapy due to high mortality associated with delayed treatment. TTP has many causes including heritable syndromes, ADAMTS13 deficiency, and drugs-related etiologies. Profound vitamin B12 deficiency can, in rare cases, mimic TTP in presentation, and since plasmapheresis can be of limited benefit, prompt diagnosis is necessary for accurate treatment with B12. Therefore, careful analysis of all clinical signs, symptoms, and labs must be assessed. We report a patient who presented with a diagnosis of TTP, and repeat assessment confirmed a diagnosis of sever vitamin B12 (B12) deficiency with pancytopenia who was appropriately treated with B12. |
| format | Article |
| id | doaj-art-26ee61ae4c274a008b7c7b2d3e0607aa |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-26ee61ae4c274a008b7c7b2d3e0607aa2025-08-20T03:54:51ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/15293061529306A Rare Cause of Thrombotic Thrombocytopenia Purpura- (TTP-) Like Syndrome, Vitamin B12 Deficiency: Interpretation of Significant Pathological FindingsMorgan Bailey0Travis Maestas1Robert Betancourt2Dalia Mikhael3Hani M. Babiker4Department of Internal Medicine, University of Arizona, Tucson, AZ, USADepartment of Internal Medicine, University of Arizona, Tucson, AZ, USADepartment of Internal Medicine, University of Arizona, Tucson, AZ, USADepartment of Internal Medicine, Banner University Medical Center-Tucson, Tucson, AZ, USADepartment of Hematology-Oncology, University of Arizona Cancer Center, Tucson, AZ, USAThrombotic thrombocytopenia purpura (TTP) is a hematological emergency that requires rapid assessment followed by prompt initiation of therapy due to high mortality associated with delayed treatment. TTP has many causes including heritable syndromes, ADAMTS13 deficiency, and drugs-related etiologies. Profound vitamin B12 deficiency can, in rare cases, mimic TTP in presentation, and since plasmapheresis can be of limited benefit, prompt diagnosis is necessary for accurate treatment with B12. Therefore, careful analysis of all clinical signs, symptoms, and labs must be assessed. We report a patient who presented with a diagnosis of TTP, and repeat assessment confirmed a diagnosis of sever vitamin B12 (B12) deficiency with pancytopenia who was appropriately treated with B12.http://dx.doi.org/10.1155/2019/1529306 |
| spellingShingle | Morgan Bailey Travis Maestas Robert Betancourt Dalia Mikhael Hani M. Babiker A Rare Cause of Thrombotic Thrombocytopenia Purpura- (TTP-) Like Syndrome, Vitamin B12 Deficiency: Interpretation of Significant Pathological Findings Case Reports in Hematology |
| title | A Rare Cause of Thrombotic Thrombocytopenia Purpura- (TTP-) Like Syndrome, Vitamin B12 Deficiency: Interpretation of Significant Pathological Findings |
| title_full | A Rare Cause of Thrombotic Thrombocytopenia Purpura- (TTP-) Like Syndrome, Vitamin B12 Deficiency: Interpretation of Significant Pathological Findings |
| title_fullStr | A Rare Cause of Thrombotic Thrombocytopenia Purpura- (TTP-) Like Syndrome, Vitamin B12 Deficiency: Interpretation of Significant Pathological Findings |
| title_full_unstemmed | A Rare Cause of Thrombotic Thrombocytopenia Purpura- (TTP-) Like Syndrome, Vitamin B12 Deficiency: Interpretation of Significant Pathological Findings |
| title_short | A Rare Cause of Thrombotic Thrombocytopenia Purpura- (TTP-) Like Syndrome, Vitamin B12 Deficiency: Interpretation of Significant Pathological Findings |
| title_sort | rare cause of thrombotic thrombocytopenia purpura ttp like syndrome vitamin b12 deficiency interpretation of significant pathological findings |
| url | http://dx.doi.org/10.1155/2019/1529306 |
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