Flaxseed extract: A potential therapeutic intervention for type-2 diabetes mellitus and cardiovascular risk reduction in Wistar rats
Introduction: Type 2 diabetes mellitus (T2DM) affects millions of people worldwide, highlighting the importance of dietary interventions. Flaxseed (Linum usitatissimum L.) has shown promise in treating chronic metabolic diseases. This study investigates the therapeutic potential of flaxseed as an an...
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Shahrekord University of Medical Sciences
2024-10-01
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| Series: | Journal of HerbMed Pharmacology |
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| Online Access: | https://herbmedpharmacol.com/PDF/jhp-13-587.pdf |
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| author | Patonah Hasimun Herni Kusriani Yani Mulyani Nurasyfa Syaumi |
| author_facet | Patonah Hasimun Herni Kusriani Yani Mulyani Nurasyfa Syaumi |
| author_sort | Patonah Hasimun |
| collection | DOAJ |
| description | Introduction: Type 2 diabetes mellitus (T2DM) affects millions of people worldwide, highlighting the importance of dietary interventions. Flaxseed (Linum usitatissimum L.) has shown promise in treating chronic metabolic diseases. This study investigates the therapeutic potential of flaxseed as an antidiabetic agent and its protective effect on cardiovascular diseases. Methods: Rats were randomly divided into five groups: normal fed with drug carrier group (N), diabetes with drug carrier group (D), diabetes with metformin (M) group (D+M), and diabetes with flaxseed extract doses of 100 and 200 mg/kg (D+F1 and D+F2) groups. The diabetic rat model was established by administration of drinking water containing 25% fructose and a single intraperitoneal injection of 100 mg/kg alloxan. After a six-week intervention, the rats were sacrificed to assess the antidiabetic and cardiovascular effects. Results: The doses of 100 and 200 mg/kg flaxseed extract significantly reduced body weight and fasting glucose levels and increased insulin sensitivity index (KITT) compared to the diabetes group (P<0.05). In addition, histological analysis showed a significant improvement and increase in pancreatic beta cells in the treatment group compared to the diabetes group (P<0.05). Flaxseed extract doses of 100 and 200 mg/kg significantly reduced weight gain and insulin resistance, contributing to decreased arterial stiffness and atherogenic index compared to the diabetic group (P<0.05). The hypoglycemic effect suggested a dose-dependent response. Conclusion: Flaxseed extract regulates blood glucose levels probably by enhancing insulin sensitivity and revitalizing damaged pancreatic beta cells. It mitigates cardiovascular risk, by reducing arterial stiffness and atherogenicity. |
| format | Article |
| id | doaj-art-26e95211feae4e9699da03bae6df3347 |
| institution | OA Journals |
| issn | 2345-5004 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Journal of HerbMed Pharmacology |
| spelling | doaj-art-26e95211feae4e9699da03bae6df33472025-08-20T02:38:49ZengShahrekord University of Medical SciencesJournal of HerbMed Pharmacology2345-50042024-10-0113458759510.34172/jhp.2024.51457jhp-51457Flaxseed extract: A potential therapeutic intervention for type-2 diabetes mellitus and cardiovascular risk reduction in Wistar ratsPatonah Hasimun0Herni Kusriani1Yani Mulyani2Nurasyfa Syaumi3Faculty of Pharmacy, Bhakti Kencana University, Bandung-40614, West Java, IndonesiaFaculty of Pharmacy, Bhakti Kencana University, Bandung-40614, West Java, IndonesiaFaculty of Pharmacy, Bhakti Kencana University, Bandung-40614, West Java, IndonesiaFaculty of Pharmacy, Bhakti Kencana University, Bandung-40614, West Java, IndonesiaIntroduction: Type 2 diabetes mellitus (T2DM) affects millions of people worldwide, highlighting the importance of dietary interventions. Flaxseed (Linum usitatissimum L.) has shown promise in treating chronic metabolic diseases. This study investigates the therapeutic potential of flaxseed as an antidiabetic agent and its protective effect on cardiovascular diseases. Methods: Rats were randomly divided into five groups: normal fed with drug carrier group (N), diabetes with drug carrier group (D), diabetes with metformin (M) group (D+M), and diabetes with flaxseed extract doses of 100 and 200 mg/kg (D+F1 and D+F2) groups. The diabetic rat model was established by administration of drinking water containing 25% fructose and a single intraperitoneal injection of 100 mg/kg alloxan. After a six-week intervention, the rats were sacrificed to assess the antidiabetic and cardiovascular effects. Results: The doses of 100 and 200 mg/kg flaxseed extract significantly reduced body weight and fasting glucose levels and increased insulin sensitivity index (KITT) compared to the diabetes group (P<0.05). In addition, histological analysis showed a significant improvement and increase in pancreatic beta cells in the treatment group compared to the diabetes group (P<0.05). Flaxseed extract doses of 100 and 200 mg/kg significantly reduced weight gain and insulin resistance, contributing to decreased arterial stiffness and atherogenic index compared to the diabetic group (P<0.05). The hypoglycemic effect suggested a dose-dependent response. Conclusion: Flaxseed extract regulates blood glucose levels probably by enhancing insulin sensitivity and revitalizing damaged pancreatic beta cells. It mitigates cardiovascular risk, by reducing arterial stiffness and atherogenicity.https://herbmedpharmacol.com/PDF/jhp-13-587.pdfflaxseedinsulin resistancediabetes mellitusarterial stiffnessatherogenic index |
| spellingShingle | Patonah Hasimun Herni Kusriani Yani Mulyani Nurasyfa Syaumi Flaxseed extract: A potential therapeutic intervention for type-2 diabetes mellitus and cardiovascular risk reduction in Wistar rats Journal of HerbMed Pharmacology flaxseed insulin resistance diabetes mellitus arterial stiffness atherogenic index |
| title | Flaxseed extract: A potential therapeutic intervention for type-2 diabetes mellitus and cardiovascular risk reduction in Wistar rats |
| title_full | Flaxseed extract: A potential therapeutic intervention for type-2 diabetes mellitus and cardiovascular risk reduction in Wistar rats |
| title_fullStr | Flaxseed extract: A potential therapeutic intervention for type-2 diabetes mellitus and cardiovascular risk reduction in Wistar rats |
| title_full_unstemmed | Flaxseed extract: A potential therapeutic intervention for type-2 diabetes mellitus and cardiovascular risk reduction in Wistar rats |
| title_short | Flaxseed extract: A potential therapeutic intervention for type-2 diabetes mellitus and cardiovascular risk reduction in Wistar rats |
| title_sort | flaxseed extract a potential therapeutic intervention for type 2 diabetes mellitus and cardiovascular risk reduction in wistar rats |
| topic | flaxseed insulin resistance diabetes mellitus arterial stiffness atherogenic index |
| url | https://herbmedpharmacol.com/PDF/jhp-13-587.pdf |
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