Promoting ER stress in a plasmacytoid dendritic cell line drives fibroblast activation

Promoting ER stress in a plasmacytoid dendritic cell line drives fibroblast activation

Abstract Background Fibrosis remains a major complication in several chronic diseases, including systemic sclerosis (SSc). Plasmacytoid dendritic cells (pDCs) are innate immune cells that play a key role in the development of fibrosis in SSc patients, through still poorly defined mechanisms. Interes...

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Bibliographic Details
Main Authors: Beatriz H. Ferreira, Inês S. Silva, Andreia Mendes, Fátima Leite-Pinheiro, Adrienne W. Paton, James C. Paton, Iola F. Duarte, Philippe Pierre, Catarina R. Almeida
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cell Communication and Signaling
Subjects:
UPR
PERK
Cell-cell communication
Fibrosis
Plasmacytoid dendritic cells
Fibroblasts
Online Access:https://doi.org/10.1186/s12964-025-02057-7
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