Sense and Nonsense of an Extended Pelvic Lymph Node Dissection in Prostate Cancer
Lymph node metastases associated with prostate cancer (PCa) has been shown to be a poor prognostic factor. The role of pelvic lymph node dissection (PLND) itself in relation to survival remains unclear, however. A Medline search was conducted to address this issue. The following conclusions were dra...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2012/983058 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565011671678976 |
|---|---|
| author | Anthony Van Baelen Nicolas Mottet Martin Spahn Alberto Briganti Paolo Gontero Steven Joniau |
| author_facet | Anthony Van Baelen Nicolas Mottet Martin Spahn Alberto Briganti Paolo Gontero Steven Joniau |
| author_sort | Anthony Van Baelen |
| collection | DOAJ |
| description | Lymph node metastases associated with prostate cancer (PCa) has been shown to be a poor prognostic factor. The role of pelvic lymph node dissection (PLND) itself in relation to survival remains unclear, however. A Medline search was conducted to address this issue. The following conclusions were drawn. Only recently, improved survival due to completion of radical prostatectomy (RP) (compared to abandoning RP) in known or presumed lymph-node-positive patients has been shown. Lymph node sampling can only be considered representative if an adequate number of nodes is removed. While several authors have suggested that a therapeutic benefit in patients undergoing RP is not provided by PLND, the reliability of these studies is uncertain. Contrary to this, several studies have indicated the possibility of long-term survival even in the presence of limited lymph node metastases. The role and timing of initiation of adjuvant androgen deprivation therapy (ADT) in patients who have node-positive disease after RP is controversial. Recent studies suggest that delaying ADT may not adversely impact survival. |
| format | Article |
| id | doaj-art-26dcea8de4ea4cdb9a2f0bedc0626504 |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-26dcea8de4ea4cdb9a2f0bedc06265042025-02-03T01:09:31ZengWileyAdvances in Urology1687-63691687-63772012-01-01201210.1155/2012/983058983058Sense and Nonsense of an Extended Pelvic Lymph Node Dissection in Prostate CancerAnthony Van Baelen0Nicolas Mottet1Martin Spahn2Alberto Briganti3Paolo Gontero4Steven Joniau5Department of Urology, University Hospitals Leuven, 3000 Leuven, BelgiumDepartment of Urology, Clinique Mutualiste de la Loire, 42013 Saint-Etienne, FranceDepartment of Urology, University of Würzburg, 97070 Würzburg, GermanyDepartment of Urology, Vita-Salute University, 20132 Milan, ItalyDepartment of Urology, University of Turin, 10129 Turin, ItalyDepartment of Urology, University Hospitals Leuven, 3000 Leuven, BelgiumLymph node metastases associated with prostate cancer (PCa) has been shown to be a poor prognostic factor. The role of pelvic lymph node dissection (PLND) itself in relation to survival remains unclear, however. A Medline search was conducted to address this issue. The following conclusions were drawn. Only recently, improved survival due to completion of radical prostatectomy (RP) (compared to abandoning RP) in known or presumed lymph-node-positive patients has been shown. Lymph node sampling can only be considered representative if an adequate number of nodes is removed. While several authors have suggested that a therapeutic benefit in patients undergoing RP is not provided by PLND, the reliability of these studies is uncertain. Contrary to this, several studies have indicated the possibility of long-term survival even in the presence of limited lymph node metastases. The role and timing of initiation of adjuvant androgen deprivation therapy (ADT) in patients who have node-positive disease after RP is controversial. Recent studies suggest that delaying ADT may not adversely impact survival.http://dx.doi.org/10.1155/2012/983058 |
| spellingShingle | Anthony Van Baelen Nicolas Mottet Martin Spahn Alberto Briganti Paolo Gontero Steven Joniau Sense and Nonsense of an Extended Pelvic Lymph Node Dissection in Prostate Cancer Advances in Urology |
| title | Sense and Nonsense of an Extended Pelvic Lymph Node Dissection in Prostate Cancer |
| title_full | Sense and Nonsense of an Extended Pelvic Lymph Node Dissection in Prostate Cancer |
| title_fullStr | Sense and Nonsense of an Extended Pelvic Lymph Node Dissection in Prostate Cancer |
| title_full_unstemmed | Sense and Nonsense of an Extended Pelvic Lymph Node Dissection in Prostate Cancer |
| title_short | Sense and Nonsense of an Extended Pelvic Lymph Node Dissection in Prostate Cancer |
| title_sort | sense and nonsense of an extended pelvic lymph node dissection in prostate cancer |
| url | http://dx.doi.org/10.1155/2012/983058 |
| work_keys_str_mv | AT anthonyvanbaelen senseandnonsenseofanextendedpelviclymphnodedissectioninprostatecancer AT nicolasmottet senseandnonsenseofanextendedpelviclymphnodedissectioninprostatecancer AT martinspahn senseandnonsenseofanextendedpelviclymphnodedissectioninprostatecancer AT albertobriganti senseandnonsenseofanextendedpelviclymphnodedissectioninprostatecancer AT paologontero senseandnonsenseofanextendedpelviclymphnodedissectioninprostatecancer AT stevenjoniau senseandnonsenseofanextendedpelviclymphnodedissectioninprostatecancer |