ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES
Abstract. Taking into account close localization of genes encoding HSP70-2 and TNFα and mutual influence of their products upon development of septic process, we investigated allelic polymorphism in the coding region of HSP70-2 gene at position 1267, and a promoter polymorphism of TNFα gene (–308 po...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/199 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849339468348129280 |
|---|---|
| author | A. V. Shevchenko O. V. Golovanova V. I. Konenkov E. I. Streltsova |
| author_facet | A. V. Shevchenko O. V. Golovanova V. I. Konenkov E. I. Streltsova |
| author_sort | A. V. Shevchenko |
| collection | DOAJ |
| description | Abstract. Taking into account close localization of genes encoding HSP70-2 and TNFα and mutual influence of their products upon development of septic process, we investigated allelic polymorphism in the coding region of HSP70-2 gene at position 1267, and a promoter polymorphism of TNFα gene (–308 position) in sixty-one patients with surgical sepsis, as compared with 100 healthy donors, assuming that certain genomic variants can be associated with susceptibility for sepsis and/or fatal outcomes in severe sepsis. Significant differences in frequencies of HSP70-2 gene alleles have been found in the group with sepsis against healthy controls. Prevalence of HSP70-2*B/B allele is increased in the group of patients with sepsis, and a predisposal for sepsis development is shown for carriers of the given genotype. When analyzing carriers of combined HSP70-2/TNFα allelic variants among dead patients vs survivors, we have revealed specific combinations that are detected solely among non-survived patients, i.e., HSP70-2 A/TNFα AA, or only among survivors (HSP70-2BB /TNFα AA и HSP70-2 BB/TNFα AG). The results obtained allow us to suggest about certain genetic factors that may sufficiently influence intensity of inflammation in sepsis and, hence, upon clinical manifestations and outcomes of the disease. |
| format | Article |
| id | doaj-art-26da536dd5c84680bcfa65d9cf2991ec |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-26da536dd5c84680bcfa65d9cf2991ec2025-08-20T03:44:07ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0194-542943410.15789/1563-0625-2007-4-5-429-434196ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENESA. V. Shevchenko0O. V. Golovanova1V. I. Konenkov2E. I. Streltsova3ГУ НИИ Клинической и Экспериментальной Лимфологии СО РАМН, г. НовосибирскГУ НИИ Клинической и Экспериментальной Лимфологии СО РАМН, г. НовосибирскГУ НИИ Клинической и Экспериментальной Лимфологии СО РАМН, г. НовосибирскГосударственная Новосибирская Областная Клиническая больница, г. НовосибирскAbstract. Taking into account close localization of genes encoding HSP70-2 and TNFα and mutual influence of their products upon development of septic process, we investigated allelic polymorphism in the coding region of HSP70-2 gene at position 1267, and a promoter polymorphism of TNFα gene (–308 position) in sixty-one patients with surgical sepsis, as compared with 100 healthy donors, assuming that certain genomic variants can be associated with susceptibility for sepsis and/or fatal outcomes in severe sepsis. Significant differences in frequencies of HSP70-2 gene alleles have been found in the group with sepsis against healthy controls. Prevalence of HSP70-2*B/B allele is increased in the group of patients with sepsis, and a predisposal for sepsis development is shown for carriers of the given genotype. When analyzing carriers of combined HSP70-2/TNFα allelic variants among dead patients vs survivors, we have revealed specific combinations that are detected solely among non-survived patients, i.e., HSP70-2 A/TNFα AA, or only among survivors (HSP70-2BB /TNFα AA и HSP70-2 BB/TNFα AG). The results obtained allow us to suggest about certain genetic factors that may sufficiently influence intensity of inflammation in sepsis and, hence, upon clinical manifestations and outcomes of the disease.https://www.mimmun.ru/mimmun/article/view/199tnfαhsp70-2surgical sepsis |
| spellingShingle | A. V. Shevchenko O. V. Golovanova V. I. Konenkov E. I. Streltsova ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES Медицинская иммунология tnfα hsp70-2 surgical sepsis |
| title | ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES |
| title_full | ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES |
| title_fullStr | ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES |
| title_full_unstemmed | ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES |
| title_short | ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES |
| title_sort | association of lethal outcomes in surgical sepsis with allelic variants of tnf α and heat shock protein hsp70 2 genes |
| topic | tnfα hsp70-2 surgical sepsis |
| url | https://www.mimmun.ru/mimmun/article/view/199 |
| work_keys_str_mv | AT avshevchenko associationoflethaloutcomesinsurgicalsepsiswithallelicvariantsoftnfaandheatshockproteinhsp702genes AT ovgolovanova associationoflethaloutcomesinsurgicalsepsiswithallelicvariantsoftnfaandheatshockproteinhsp702genes AT vikonenkov associationoflethaloutcomesinsurgicalsepsiswithallelicvariantsoftnfaandheatshockproteinhsp702genes AT eistreltsova associationoflethaloutcomesinsurgicalsepsiswithallelicvariantsoftnfaandheatshockproteinhsp702genes |