ESBL-Producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Exhibit Divergent Paths During In-Human Evolution Towards Carbapenem Resistance

ESBL-Producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> Exhibit Divergent Paths During In-Human Evolution Towards Carbapenem Resistance

Treatment of infections caused by ESBL-producing <i>Escherichia coli</i> (EC) and <i>Klebsiella pneumoniae</i> (KP) with carbapenem antibiotics can lead to the development of carbapenem resistance over time through the acquisition of porin mutations and plasmids bearing <i...

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Bibliographic Details
Main Authors: Michelle Chioma Kalu, Akanksha Acharya, Peter Jorth, Annie Wong-Beringer
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Microorganisms
Subjects:
carbapenem resistance
ESBL-producing <i>Enterobacterales</i>
genetic evolution
CRISPR-Cas
Online Access:https://www.mdpi.com/2076-2607/13/6/1387
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