Exploring the role of EMT in ovarian cancer progression using a multiscale mathematical model
Abstract Epithelial-to-mesenchymal transition (EMT) plays a key role in the progression of cancer tumours, significantly reducing the success of treatment. EMT occurs when a cell undergoes phenotypical changes, resulting in enhanced drug resistance, higher cell plasticity, and increased metastatic a...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-04-01
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| Series: | npj Systems Biology and Applications |
| Online Access: | https://doi.org/10.1038/s41540-025-00508-y |
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| author | Samuel Oliver Michael Williams Mohit Kumar Jolly Deyarina Gonzalez Gibin Powathil |
| author_facet | Samuel Oliver Michael Williams Mohit Kumar Jolly Deyarina Gonzalez Gibin Powathil |
| author_sort | Samuel Oliver |
| collection | DOAJ |
| description | Abstract Epithelial-to-mesenchymal transition (EMT) plays a key role in the progression of cancer tumours, significantly reducing the success of treatment. EMT occurs when a cell undergoes phenotypical changes, resulting in enhanced drug resistance, higher cell plasticity, and increased metastatic abilities. Here, we employ a 3D agent-based multiscale modelling framework using PhysiCell to explore the role of EMT over time in two cell lines, OVCAR-3 and SKOV-3. This approach allows us to investigate the spatiotemporal progression of ovarian cancer and the impacts of the conditions in the microenvironment. OVCAR-3 and SKOV-3 cell lines possess highly contrasting tumour layouts, allowing a wide range of different tumour dynamics and morphologies to be tested and studied. Along with performing sensitivity analysis on the model, simulation results capture the biological observations and trends seen in tumour growth and development, thus helping to obtain further insights into OVCAR-3 and SKOV-3 cell line dynamics. |
| format | Article |
| id | doaj-art-26d4a1dae46b43d08da8bc2611b0536d |
| institution | OA Journals |
| issn | 2056-7189 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Systems Biology and Applications |
| spelling | doaj-art-26d4a1dae46b43d08da8bc2611b0536d2025-08-20T02:28:08ZengNature Portfolionpj Systems Biology and Applications2056-71892025-04-0111111810.1038/s41540-025-00508-yExploring the role of EMT in ovarian cancer progression using a multiscale mathematical modelSamuel Oliver0Michael Williams1Mohit Kumar Jolly2Deyarina Gonzalez3Gibin Powathil4Department of Mathematics, Swansea UniversityDepartment of Biomedical Sciences, Swansea UniversityDepartment of Bioengineering, Indian Institute of ScienceDepartment of Biomedical Sciences, Swansea UniversityDepartment of Mathematics, Swansea UniversityAbstract Epithelial-to-mesenchymal transition (EMT) plays a key role in the progression of cancer tumours, significantly reducing the success of treatment. EMT occurs when a cell undergoes phenotypical changes, resulting in enhanced drug resistance, higher cell plasticity, and increased metastatic abilities. Here, we employ a 3D agent-based multiscale modelling framework using PhysiCell to explore the role of EMT over time in two cell lines, OVCAR-3 and SKOV-3. This approach allows us to investigate the spatiotemporal progression of ovarian cancer and the impacts of the conditions in the microenvironment. OVCAR-3 and SKOV-3 cell lines possess highly contrasting tumour layouts, allowing a wide range of different tumour dynamics and morphologies to be tested and studied. Along with performing sensitivity analysis on the model, simulation results capture the biological observations and trends seen in tumour growth and development, thus helping to obtain further insights into OVCAR-3 and SKOV-3 cell line dynamics.https://doi.org/10.1038/s41540-025-00508-y |
| spellingShingle | Samuel Oliver Michael Williams Mohit Kumar Jolly Deyarina Gonzalez Gibin Powathil Exploring the role of EMT in ovarian cancer progression using a multiscale mathematical model npj Systems Biology and Applications |
| title | Exploring the role of EMT in ovarian cancer progression using a multiscale mathematical model |
| title_full | Exploring the role of EMT in ovarian cancer progression using a multiscale mathematical model |
| title_fullStr | Exploring the role of EMT in ovarian cancer progression using a multiscale mathematical model |
| title_full_unstemmed | Exploring the role of EMT in ovarian cancer progression using a multiscale mathematical model |
| title_short | Exploring the role of EMT in ovarian cancer progression using a multiscale mathematical model |
| title_sort | exploring the role of emt in ovarian cancer progression using a multiscale mathematical model |
| url | https://doi.org/10.1038/s41540-025-00508-y |
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