Hypoxia drives progression of multiple sclerosis by enhancing the inflammasome activation in macrophages with Porphyromonas gingivalis infection

Hypoxia drives progression of multiple sclerosis by enhancing the inflammasome activation in macrophages with Porphyromonas gingivalis infection

Abstract Porphyromonas gingivalis (Pg), a gram-negative anaerobic bacterium, is a leading pathogen causing periodontitis. It secretes several virulence factors, including gingipains, lipopolysaccharides (LPS), and outer membrane vesicles (OMVs), which can trigger the release of inflammatory cytokine...

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Main Authors: Tokuju Okano, Hiroshi Ashida, Masayuki Tsukasaki, Tamako Iida, Masahiro Yamamoto, Hiroshi Takayanagi, Takeharu Sakamoto, Toshihiko Suzuki
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02548-z
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