Neuroprotective Potential of Nitroglycerin in Ischemic Stroke: Insights into Neural Glucose Metabolism and Endoplasmic Reticulum Stress Inhibition

Neuroprotective Potential of Nitroglycerin in Ischemic Stroke: Insights into Neural Glucose Metabolism and Endoplasmic Reticulum Stress Inhibition

Background Glyceryl trinitrate (GTN), also known as nitroglycerin, is predominantly recognized as a vasodilator for ischemic heart disease, and its potential neuroprotective properties in acute ischemic stroke remain under exploration. We sought to discover the therapeutic advantages and mechanisms...

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Bibliographic Details
Main Authors: Shangqian Jiang, Yuchuan Ding, Hongrui Wang, Enoch Kim, Xiaokun Geng
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cell death
gluconeogenesis
hyperglycolysis
NO‐cGMP‐PKG signaling
post‐recanalization neuroprotection
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.035382
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