Diagnostic Value of Stimulated Serum Thyroglobulin in the Follow-up of Patients with Differentiated Thyroid Cancer
The aim was to determine the diagnostic value of stimulated serum thyroglobulin (sTg) for the follow-up of patients with differentiated thyroid cancer (DTC) and to evaluate whether repeated sTg measurement provides additional clinical benefit in detecting persistent or recurrent structural diseas...
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2024-01-01
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| Series: | Acta Clinica Croatica |
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| Online Access: | https://hrcak.srce.hr/file/481670 |
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| author | Vlado Wagenhofer Ivan Mihaljević Tatjana Kralj Dubravka Vrdoljak Tomislav Kizivat |
| author_facet | Vlado Wagenhofer Ivan Mihaljević Tatjana Kralj Dubravka Vrdoljak Tomislav Kizivat |
| author_sort | Vlado Wagenhofer |
| collection | DOAJ |
| description | The aim was to determine the diagnostic value of stimulated serum thyroglobulin
(sTg) for the follow-up of patients with differentiated thyroid cancer (DTC) and to evaluate whether
repeated sTg measurement provides additional clinical benefit in detecting persistent or recurrent structural
disease if the initial sTg was negative. The retrospective study included 388 consecutive patients
with DTC treated and followed-up between 2004 and 2018 at the Clinical Institute of Nuclear Medicine
and Radiation Protection, Osijek University Hospital. The negative predictive value (NPV) of the
first sTg measured 12 months after the initial treatment was compared with NPV of sTg measured
annually during 3 consecutive years of follow-up. The first sTg NPV was 99.5% in the group of lowrisk
patients and 96.1% in the group of intermediate-risk patients. In both low- and intermediate-risk
groups, there were no differences between the first sTg NPV and NPV of sTg measured annually during
3 years of follow-up period. Repeated measurement of the sTg after initially negative result had a limited
clinical value for detecting persistent or recurrent structural disease and cannot be recommended in
routine follow-up of low- and intermediate-risk patients with DTC. |
| format | Article |
| id | doaj-art-26c4be64e2754c2f826af1a4e2eacaa8 |
| institution | Kabale University |
| issn | 0353-9466 1333-9451 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj-art-26c4be64e2754c2f826af1a4e2eacaa82025-08-20T03:28:55ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512024-01-0163.3-446847310.20471/acc.2024.63.03-04.02Diagnostic Value of Stimulated Serum Thyroglobulin in the Follow-up of Patients with Differentiated Thyroid CancerVlado Wagenhofer0Ivan Mihaljević1Tatjana Kralj2Dubravka Vrdoljak3Tomislav Kizivat4Clinical Institute of Nuclear Medicine and Radiation Protection, University Hospital Osijek, Osijek, Croatia; Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, CroatiaClinical Institute of Nuclear Medicine and Radiation Protection, University Hospital Osijek, Osijek, Croatia; Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Academy of Medical Sciences of Croatia, CroatiaClinical Institute of Nuclear Medicine and Radiation Protection, University Hospital Osijek, Osijek, Croatia; Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, CroatiaClinical Institute of Nuclear Medicine and Radiation Protection, University Hospital Osijek, Osijek, Croatia;Clinical Institute of Nuclear Medicine and Radiation Protection, University Hospital Osijek, Osijek, Croatia; Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, CroatiaThe aim was to determine the diagnostic value of stimulated serum thyroglobulin (sTg) for the follow-up of patients with differentiated thyroid cancer (DTC) and to evaluate whether repeated sTg measurement provides additional clinical benefit in detecting persistent or recurrent structural disease if the initial sTg was negative. The retrospective study included 388 consecutive patients with DTC treated and followed-up between 2004 and 2018 at the Clinical Institute of Nuclear Medicine and Radiation Protection, Osijek University Hospital. The negative predictive value (NPV) of the first sTg measured 12 months after the initial treatment was compared with NPV of sTg measured annually during 3 consecutive years of follow-up. The first sTg NPV was 99.5% in the group of lowrisk patients and 96.1% in the group of intermediate-risk patients. In both low- and intermediate-risk groups, there were no differences between the first sTg NPV and NPV of sTg measured annually during 3 years of follow-up period. Repeated measurement of the sTg after initially negative result had a limited clinical value for detecting persistent or recurrent structural disease and cannot be recommended in routine follow-up of low- and intermediate-risk patients with DTC.https://hrcak.srce.hr/file/481670Thyroid cancerRisk assessmentThyroglobulin |
| spellingShingle | Vlado Wagenhofer Ivan Mihaljević Tatjana Kralj Dubravka Vrdoljak Tomislav Kizivat Diagnostic Value of Stimulated Serum Thyroglobulin in the Follow-up of Patients with Differentiated Thyroid Cancer Acta Clinica Croatica Thyroid cancer Risk assessment Thyroglobulin |
| title | Diagnostic Value of Stimulated Serum Thyroglobulin in the Follow-up of Patients with Differentiated Thyroid Cancer |
| title_full | Diagnostic Value of Stimulated Serum Thyroglobulin in the Follow-up of Patients with Differentiated Thyroid Cancer |
| title_fullStr | Diagnostic Value of Stimulated Serum Thyroglobulin in the Follow-up of Patients with Differentiated Thyroid Cancer |
| title_full_unstemmed | Diagnostic Value of Stimulated Serum Thyroglobulin in the Follow-up of Patients with Differentiated Thyroid Cancer |
| title_short | Diagnostic Value of Stimulated Serum Thyroglobulin in the Follow-up of Patients with Differentiated Thyroid Cancer |
| title_sort | diagnostic value of stimulated serum thyroglobulin in the follow up of patients with differentiated thyroid cancer |
| topic | Thyroid cancer Risk assessment Thyroglobulin |
| url | https://hrcak.srce.hr/file/481670 |
| work_keys_str_mv | AT vladowagenhofer diagnosticvalueofstimulatedserumthyroglobulininthefollowupofpatientswithdifferentiatedthyroidcancer AT ivanmihaljevic diagnosticvalueofstimulatedserumthyroglobulininthefollowupofpatientswithdifferentiatedthyroidcancer AT tatjanakralj diagnosticvalueofstimulatedserumthyroglobulininthefollowupofpatientswithdifferentiatedthyroidcancer AT dubravkavrdoljak diagnosticvalueofstimulatedserumthyroglobulininthefollowupofpatientswithdifferentiatedthyroidcancer AT tomislavkizivat diagnosticvalueofstimulatedserumthyroglobulininthefollowupofpatientswithdifferentiatedthyroidcancer |