Bio-engineered thermo-sensitive alginate/PNIA-g-CS co-polymeric injectable hydrogel laden with GDF-5 to stimulate nucleus pulposus for IVD regeneration

Bio-engineered thermo-sensitive alginate/PNIA-g-CS co-polymeric injectable hydrogel laden with GDF-5 to stimulate nucleus pulposus for IVD regeneration

Abstract Chronic back pain and disability are primarily caused by intervertebral disc degeneration (IDD) that requires novel therapies to regenerate the nucleus pulposus (NP) and restore disc function. In this study, a bioengineered thermo-sensitive injectable hydrogel composed of co-polymeric poly-...

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Bibliographic Details
Main Authors: Guangnan Chen, Chong Bian, Xiangyang Cheng, Jun Xu, Kaifeng Zhou, Yiming Zhang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Biological Engineering
Subjects:
Hydrogel
Sodium alginate
Growth differentiation factor
Stem cells
Nucleus pulposus
Intervertebral disc regeneration
Online Access:https://doi.org/10.1186/s13036-025-00520-0
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