The role of NMDAR antibody in the etiopathogenesis of schizophrenia
Damla Timucin,1 Osman Ozdemir,2 Mehmet Parlak3 1Department of Psychiatry, University of Health Sciences, Van Training and Research Hospital, Van, 2Department of Psychiatry, 3Department of Microbiology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey Abstract: Many authors hav...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2016-09-01
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| Series: | Neuropsychiatric Disease and Treatment |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-role-of-nmdar-antibody-in-the-etiopathogenesis-of-schizophrenia-peer-reviewed-fulltext-article-NDT |
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| Summary: | Damla Timucin,1 Osman Ozdemir,2 Mehmet Parlak3 1Department of Psychiatry, University of Health Sciences, Van Training and Research Hospital, Van, 2Department of Psychiatry, 3Department of Microbiology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey Abstract: Many authors have reported the presence of serum NMDAR antibodies in varying proportions of patients with schizophrenia; however, many others have not been able to confirm this. Because of the contradictory findings reported in various studies, more definitive research on this issue is required. Hence, we have investigated the NR1 subunit of NMDAR antibodies in patients with schizophrenia (n=49) and healthy controls (n=48). None of the investigated patients with schizophrenia and none of the healthy controls showed positive antibody against the NR1 subunit of the NMDAR. On the basis of this result, we conclude that the NR1 subunit of the NMDAR antibodies does not seem to have a role in schizophrenia. Keywords: schizophrenia, N-acetyl d-aspartate receptor, glutamate, antibody |
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| ISSN: | 1178-2021 |