Energy metabolism in Trypanosoma cruzi: the validated and putative bioenergetic and carbon sources
ABSTRACT Trypanosoma cruzi, along with Trypanosoma brucei and over 20 species of the genus Leishmania, constitutes a group of human pathogenic flagellated protists collectively called the “TriTryp,” posing among the best-studied protists. These organisms have complex life cycles and are transmitted...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2025-06-01
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| Series: | mBio |
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| Online Access: | https://journals.asm.org/doi/10.1128/mbio.02215-24 |
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| author | Mayke B. Alencar Sabrina Marsiccobetre Ana C. Mengarda Maria Sol Ballari Ariel M. Silber |
| author_facet | Mayke B. Alencar Sabrina Marsiccobetre Ana C. Mengarda Maria Sol Ballari Ariel M. Silber |
| author_sort | Mayke B. Alencar |
| collection | DOAJ |
| description | ABSTRACT Trypanosoma cruzi, along with Trypanosoma brucei and over 20 species of the genus Leishmania, constitutes a group of human pathogenic flagellated protists collectively called the “TriTryp,” posing among the best-studied protists. These organisms have complex life cycles and are transmitted by insects, which, along with vertebrates, serve as their natural hosts. Throughout their life cycles, these parasites encounter diverse environments with varying physical, chemical, biochemical, and biological characteristics that serve as stages for their evolutionary stories, culminating in different metabolic configurations and requirements. Here, we review the evidence for metabolic pathways that directly or indirectly participate in energy-transducing processes, discussing where appropriate the implications of the different metabolic networks in TriTryp. |
| format | Article |
| id | doaj-art-26b281ef190e4861a92ae399138765d7 |
| institution | OA Journals |
| issn | 2150-7511 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj-art-26b281ef190e4861a92ae399138765d72025-08-20T02:32:53ZengAmerican Society for MicrobiologymBio2150-75112025-06-0116610.1128/mbio.02215-24Energy metabolism in Trypanosoma cruzi: the validated and putative bioenergetic and carbon sourcesMayke B. Alencar0Sabrina Marsiccobetre1Ana C. Mengarda2Maria Sol Ballari3Ariel M. Silber4Laboratory of Biochemistry of Trypanosomatids (LaBTryps), Department of Parasitology, Institute of Biomedical Science II (ICB II), University of São Paulo, São Paulo, BrazilLaboratory of Biochemistry of Trypanosomatids (LaBTryps), Department of Parasitology, Institute of Biomedical Science II (ICB II), University of São Paulo, São Paulo, BrazilLaboratory of Biochemistry of Trypanosomatids (LaBTryps), Department of Parasitology, Institute of Biomedical Science II (ICB II), University of São Paulo, São Paulo, BrazilLaboratory of Biochemistry of Trypanosomatids (LaBTryps), Department of Parasitology, Institute of Biomedical Science II (ICB II), University of São Paulo, São Paulo, BrazilLaboratory of Biochemistry of Trypanosomatids (LaBTryps), Department of Parasitology, Institute of Biomedical Science II (ICB II), University of São Paulo, São Paulo, BrazilABSTRACT Trypanosoma cruzi, along with Trypanosoma brucei and over 20 species of the genus Leishmania, constitutes a group of human pathogenic flagellated protists collectively called the “TriTryp,” posing among the best-studied protists. These organisms have complex life cycles and are transmitted by insects, which, along with vertebrates, serve as their natural hosts. Throughout their life cycles, these parasites encounter diverse environments with varying physical, chemical, biochemical, and biological characteristics that serve as stages for their evolutionary stories, culminating in different metabolic configurations and requirements. Here, we review the evidence for metabolic pathways that directly or indirectly participate in energy-transducing processes, discussing where appropriate the implications of the different metabolic networks in TriTryp.https://journals.asm.org/doi/10.1128/mbio.02215-24Trypanosoma cruzibioenergeticsChagas diseaseamino acid metabolismcarbohydrate metabolismmitochondria |
| spellingShingle | Mayke B. Alencar Sabrina Marsiccobetre Ana C. Mengarda Maria Sol Ballari Ariel M. Silber Energy metabolism in Trypanosoma cruzi: the validated and putative bioenergetic and carbon sources mBio Trypanosoma cruzi bioenergetics Chagas disease amino acid metabolism carbohydrate metabolism mitochondria |
| title | Energy metabolism in Trypanosoma cruzi: the validated and putative bioenergetic and carbon sources |
| title_full | Energy metabolism in Trypanosoma cruzi: the validated and putative bioenergetic and carbon sources |
| title_fullStr | Energy metabolism in Trypanosoma cruzi: the validated and putative bioenergetic and carbon sources |
| title_full_unstemmed | Energy metabolism in Trypanosoma cruzi: the validated and putative bioenergetic and carbon sources |
| title_short | Energy metabolism in Trypanosoma cruzi: the validated and putative bioenergetic and carbon sources |
| title_sort | energy metabolism in trypanosoma cruzi the validated and putative bioenergetic and carbon sources |
| topic | Trypanosoma cruzi bioenergetics Chagas disease amino acid metabolism carbohydrate metabolism mitochondria |
| url | https://journals.asm.org/doi/10.1128/mbio.02215-24 |
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