DnaK of Parvimonas micra extracellular vesicles interacts with the host fibroblasts BAG3-IKK-γ axis to accelerate TNF-α secretion in oral lichen planus

DnaK of Parvimonas micra extracellular vesicles interacts with the host fibroblasts BAG3-IKK-γ axis to accelerate TNF-α secretion in oral lichen planus

Abstract Background Oral lichen planus (OLP) is one of the most frequent oral mucosal diseases associated with chronic inflammation, despite a profoundly limited understanding of its underlying pathogenic mechanisms. Results The microbiome analysis was conducted on buccal and lip mucosae, tongue dor...

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Bibliographic Details
Main Authors: Xiaoli Ji, Mengfan Zhi, Xiufeng Gu, Ying Han, Xiang Lan, Lixiang Song, Peipei Sun, Jingyuan Li, Xiangmin Qi, Qiang Feng
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Microbiome
Subjects:
Oral lichen planus
DnaK
BAG3
Outer membrane vesicles
NF-κB
Online Access:https://doi.org/10.1186/s40168-025-02151-5
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