Mycotoxins and Antifungal Drug Interactions: Implications in the Treatment of Illnesses Due to Indoor Chronic Toxigenic Mold Exposures

Chronic exposure to toxigenic molds in water-damaged buildings is an indoor environmental health problem to which escalating health and property insurance costs are raising a statewide concern in recent times. This paper reviews the structural and functional properties of mycotoxins produced by toxi...

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Main Authors: Ebere C. Anyanwu, Andrew W. Campbell, John E. Ehiri
Format: Article
Language:English
Published: Wiley 2004-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1100/tsw.2004.22
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author Ebere C. Anyanwu
Andrew W. Campbell
John E. Ehiri
author_facet Ebere C. Anyanwu
Andrew W. Campbell
John E. Ehiri
author_sort Ebere C. Anyanwu
collection DOAJ
description Chronic exposure to toxigenic molds in water-damaged buildings is an indoor environmental health problem to which escalating health and property insurance costs are raising a statewide concern in recent times. This paper reviews the structural and functional properties of mycotoxins produced by toxigenic molds and their interactive health implications with antifungal drugs. Fundamental bases of pathophysiological, neurodevelopmental, and cellular mechanisms of mycotoxic effects are evaluated. It is most likely that the interactions of mycotoxins with antifungal drugs may, at least in part, contribute to the observable persistent illnesses, antifungal drug resistance, and allergic reactions in patients exposed to chronic toxigenic molds. Safe dose level of mycotoxin in humans is not clear. Hence, the safety regulations in place at the moment remain inconclusive, precautionary, and arbitrary. Since some of the antifungal drugs are derived from molds, and since they have structural and functional groups similar to those of mycotoxins, the knowledge of their interactions are important in enhancing preventive measures.
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issn 1537-744X
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spelling doaj-art-26a46f838b9c4e7aad5d7c025fdf34102025-02-03T05:54:28ZengWileyThe Scientific World Journal1537-744X2004-01-01416717710.1100/tsw.2004.22Mycotoxins and Antifungal Drug Interactions: Implications in the Treatment of Illnesses Due to Indoor Chronic Toxigenic Mold ExposuresEbere C. Anyanwu0Andrew W. Campbell1John E. Ehiri2Cahers Neurosciences Research, Inc., 8787 Shenandoah Park Drive, Suite 122, Conroe, TX 77385, USAMedical Center for Immune, Environmental, and Toxic Disorders, Spring, TX, USADepartment of Maternal and Child Health, School of Public Health, University of Alabama at Birmingham (UAB), Ryals Public Health Building, 1665 University Boulevard, Birmingham, AL 35294-0022, USAChronic exposure to toxigenic molds in water-damaged buildings is an indoor environmental health problem to which escalating health and property insurance costs are raising a statewide concern in recent times. This paper reviews the structural and functional properties of mycotoxins produced by toxigenic molds and their interactive health implications with antifungal drugs. Fundamental bases of pathophysiological, neurodevelopmental, and cellular mechanisms of mycotoxic effects are evaluated. It is most likely that the interactions of mycotoxins with antifungal drugs may, at least in part, contribute to the observable persistent illnesses, antifungal drug resistance, and allergic reactions in patients exposed to chronic toxigenic molds. Safe dose level of mycotoxin in humans is not clear. Hence, the safety regulations in place at the moment remain inconclusive, precautionary, and arbitrary. Since some of the antifungal drugs are derived from molds, and since they have structural and functional groups similar to those of mycotoxins, the knowledge of their interactions are important in enhancing preventive measures.http://dx.doi.org/10.1100/tsw.2004.22
spellingShingle Ebere C. Anyanwu
Andrew W. Campbell
John E. Ehiri
Mycotoxins and Antifungal Drug Interactions: Implications in the Treatment of Illnesses Due to Indoor Chronic Toxigenic Mold Exposures
The Scientific World Journal
title Mycotoxins and Antifungal Drug Interactions: Implications in the Treatment of Illnesses Due to Indoor Chronic Toxigenic Mold Exposures
title_full Mycotoxins and Antifungal Drug Interactions: Implications in the Treatment of Illnesses Due to Indoor Chronic Toxigenic Mold Exposures
title_fullStr Mycotoxins and Antifungal Drug Interactions: Implications in the Treatment of Illnesses Due to Indoor Chronic Toxigenic Mold Exposures
title_full_unstemmed Mycotoxins and Antifungal Drug Interactions: Implications in the Treatment of Illnesses Due to Indoor Chronic Toxigenic Mold Exposures
title_short Mycotoxins and Antifungal Drug Interactions: Implications in the Treatment of Illnesses Due to Indoor Chronic Toxigenic Mold Exposures
title_sort mycotoxins and antifungal drug interactions implications in the treatment of illnesses due to indoor chronic toxigenic mold exposures
url http://dx.doi.org/10.1100/tsw.2004.22
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