Effect of elastic modulus of tumour and non-tumour cells on vibration-induced behaviours
Abstract The mechanical behaviour of tumour and non-tumour cells under vibration remains insufficiently explored, particularly the role of elastic modulus in dynamic responses. This study investigates the vibration-induced mechanical behaviour in cellular structures with varying elastic moduli (E =...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-97837-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Abstract The mechanical behaviour of tumour and non-tumour cells under vibration remains insufficiently explored, particularly the role of elastic modulus in dynamic responses. This study investigates the vibration-induced mechanical behaviour in cellular structures with varying elastic moduli (E = 0.1 , 1 , and 10 kPa) and aspect ratios ( $$AR = 2$$ and 4), focusing on vertical and horizontal forced vibrations. Finite element analysis was conducted to evaluate the natural frequencies, mode shapes, membrane accelerations, and stress responses. The intermediate aspect-ratio structures ( $$AR = 2$$ ) exhibited higher natural frequencies but a 64.2% increase in stress concentration, making them more susceptible to localised deformation under resonance. Conversely, higher aspect-ratio structures ( $$AR = 4$$ ) demonstrated improved vibrational stability with reduced resonance peaks and 64.6% lower localised stress. This study further confirmed that vertical vibrations generate higher stress and acceleration than horizontal vibrations owing to gravitational effects. Stress contour analysis indicated that under low-intensity vibrations, intermediate aspect-ratio structures may exceed their yield stress thresholds, leading to potential membrane rupture. These findings suggest that vibration-induced mechanical stimulation can be sensed differently depending on the elastic moduli and aspect ratios of tumour and non-tumour cells. |
|---|---|
| ISSN: | 2045-2322 |