Histamine antagonists promote cancer immunosurveillance

Recently, a cellular mini-immune system comprising infinitely expandable dendritic cells and T cells led to the discovery that histamine receptor H1 antagonists act on T cells to stimulate their proliferation and polarization toward a Th1/Tc1 phenotype and to increase their anticancer activity in th...

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Main Authors: Peng Liu, Guido Kroemer, Oliver Kepp
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:OncoImmunology
Subjects:
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2242211
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author Peng Liu
Guido Kroemer
Oliver Kepp
author_facet Peng Liu
Guido Kroemer
Oliver Kepp
author_sort Peng Liu
collection DOAJ
description Recently, a cellular mini-immune system comprising infinitely expandable dendritic cells and T cells led to the discovery that histamine receptor H1 antagonists act on T cells to stimulate their proliferation and polarization toward a Th1/Tc1 phenotype and to increase their anticancer activity in the context of immunochemotherapy.
format Article
id doaj-art-268536b220294c74a18ab889a5dc5f13
institution DOAJ
issn 2162-402X
language English
publishDate 2023-12-01
publisher Taylor & Francis Group
record_format Article
series OncoImmunology
spelling doaj-art-268536b220294c74a18ab889a5dc5f132025-08-20T02:50:44ZengTaylor & Francis GroupOncoImmunology2162-402X2023-12-0112110.1080/2162402X.2023.2242211Histamine antagonists promote cancer immunosurveillancePeng Liu0Guido Kroemer1Oliver Kepp2Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, FranceRecently, a cellular mini-immune system comprising infinitely expandable dendritic cells and T cells led to the discovery that histamine receptor H1 antagonists act on T cells to stimulate their proliferation and polarization toward a Th1/Tc1 phenotype and to increase their anticancer activity in the context of immunochemotherapy.https://www.tandfonline.com/doi/10.1080/2162402X.2023.2242211cancercell deathimmunotherapy
spellingShingle Peng Liu
Guido Kroemer
Oliver Kepp
Histamine antagonists promote cancer immunosurveillance
OncoImmunology
cancer
cell death
immunotherapy
title Histamine antagonists promote cancer immunosurveillance
title_full Histamine antagonists promote cancer immunosurveillance
title_fullStr Histamine antagonists promote cancer immunosurveillance
title_full_unstemmed Histamine antagonists promote cancer immunosurveillance
title_short Histamine antagonists promote cancer immunosurveillance
title_sort histamine antagonists promote cancer immunosurveillance
topic cancer
cell death
immunotherapy
url https://www.tandfonline.com/doi/10.1080/2162402X.2023.2242211
work_keys_str_mv AT pengliu histamineantagonistspromotecancerimmunosurveillance
AT guidokroemer histamineantagonistspromotecancerimmunosurveillance
AT oliverkepp histamineantagonistspromotecancerimmunosurveillance