Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved]
The translation of animal-based biomedical research into clinical research is often inadequate. Maximizing translation should be central to animal research on human diseases, guiding researchers in study design and animal model selection. However, practical considerations often drive the choice of a...
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F1000 Research Ltd
2024-11-01
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| Online Access: | https://f1000research.com/articles/13-858/v2 |
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| author | Céline Heinl Ines Schadock Maximilian Wurm Paul Lucas Wildner Daniel Butzke Bettina Bert Alexandra Bannach-Brown Matthias Steinfath Kai Diederich |
| author_facet | Céline Heinl Ines Schadock Maximilian Wurm Paul Lucas Wildner Daniel Butzke Bettina Bert Alexandra Bannach-Brown Matthias Steinfath Kai Diederich |
| author_sort | Céline Heinl |
| collection | DOAJ |
| description | The translation of animal-based biomedical research into clinical research is often inadequate. Maximizing translation should be central to animal research on human diseases, guiding researchers in study design and animal model selection. However, practical considerations often drive the choice of animal model, which may not always reflect key patient characteristics, such as sex and age, impacting the disease's course. Despite diseases affecting both sexes, researchers frequently use male mice. To address this imbalance, journals and funding agencies have begun questioning the sex of animals used in studies and issued new guidelines. Conversely, the age of rodents is rarely discussed, even though many diseases primarily affect older patients. Young mice are commonly used, even in studies of diseases affecting older adults. Systematic comparisons between the age of rodents used and the age of patients in clinical trials are lacking. In this review, we systematically analyze the age and sex of mice used to model the five leading causes of global disability-adjusted life-years over the age of 75. We compare the results with the age and sex of patients in clinical trials focusing on Alzheimer's disease, stroke, type 2 diabetes mellitus, ischemic heart disease, and chronic obstructive pulmonary disease. We also analyze whether the age of the mice used has changed over the past decade. By systematically assessing the age and sex of the mice, we aim to initiate a discussion on the appropriate choice of animal model to improve the translatability of research results. |
| format | Article |
| id | doaj-art-267ae633a4ac48599d81837cc6c05d99 |
| institution | Kabale University |
| issn | 2046-1402 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj-art-267ae633a4ac48599d81837cc6c05d992025-01-21T01:00:01ZengF1000 Research LtdF1000Research2046-14022024-11-0113174899Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved]Céline Heinl0https://orcid.org/0000-0003-3369-1939Ines Schadock1https://orcid.org/0000-0002-6717-6276Maximilian Wurm2Paul Lucas Wildner3Daniel Butzke4Bettina Bert5Alexandra Bannach-Brown6https://orcid.org/0000-0002-3161-1395Matthias Steinfath7Kai Diederich8https://orcid.org/0000-0002-6550-9460German Centre for the Protection of Laboratory Animals (Bf3R), German Federal Institute for Risk Assessment (BfR), Berlin, Berlin, GermanyGerman Centre for the Protection of Laboratory Animals (Bf3R), German Federal Institute for Risk Assessment (BfR), Berlin, Berlin, GermanyCharite University Hospital, Berlin, GermanyCharite University Hospital, Berlin, GermanyGerman Centre for the Protection of Laboratory Animals (Bf3R), German Federal Institute for Risk Assessment (BfR), Berlin, Berlin, GermanyGerman Centre for the Protection of Laboratory Animals (Bf3R), German Federal Institute for Risk Assessment (BfR), Berlin, Berlin, GermanyQUEST Center, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Berlin, GermanyGerman Centre for the Protection of Laboratory Animals (Bf3R), German Federal Institute for Risk Assessment (BfR), Berlin, Berlin, GermanyGerman Centre for the Protection of Laboratory Animals (Bf3R), German Federal Institute for Risk Assessment (BfR), Berlin, Berlin, GermanyThe translation of animal-based biomedical research into clinical research is often inadequate. Maximizing translation should be central to animal research on human diseases, guiding researchers in study design and animal model selection. However, practical considerations often drive the choice of animal model, which may not always reflect key patient characteristics, such as sex and age, impacting the disease's course. Despite diseases affecting both sexes, researchers frequently use male mice. To address this imbalance, journals and funding agencies have begun questioning the sex of animals used in studies and issued new guidelines. Conversely, the age of rodents is rarely discussed, even though many diseases primarily affect older patients. Young mice are commonly used, even in studies of diseases affecting older adults. Systematic comparisons between the age of rodents used and the age of patients in clinical trials are lacking. In this review, we systematically analyze the age and sex of mice used to model the five leading causes of global disability-adjusted life-years over the age of 75. We compare the results with the age and sex of patients in clinical trials focusing on Alzheimer's disease, stroke, type 2 diabetes mellitus, ischemic heart disease, and chronic obstructive pulmonary disease. We also analyze whether the age of the mice used has changed over the past decade. By systematically assessing the age and sex of the mice, we aim to initiate a discussion on the appropriate choice of animal model to improve the translatability of research results.https://f1000research.com/articles/13-858/v2systematic review experimental animals age sex translationeng |
| spellingShingle | Céline Heinl Ines Schadock Maximilian Wurm Paul Lucas Wildner Daniel Butzke Bettina Bert Alexandra Bannach-Brown Matthias Steinfath Kai Diederich Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved] F1000Research systematic review experimental animals age sex translation eng |
| title | Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved] |
| title_full | Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved] |
| title_fullStr | Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved] |
| title_full_unstemmed | Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved] |
| title_short | Protocol for the systematic review of age and sex in preclinical models of age-correlated diseases [version 2; peer review: 2 approved] |
| title_sort | protocol for the systematic review of age and sex in preclinical models of age correlated diseases version 2 peer review 2 approved |
| topic | systematic review experimental animals age sex translation eng |
| url | https://f1000research.com/articles/13-858/v2 |
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