In Silico Characterization of Resistance and Virulence Genes in <i>Aeromonas jandaei</i> Strains Isolated from <i>Oreochromis niloticus</i> in Brazil
Understanding the genetic characteristics of <i>Aeromonas jandaei</i> in Brazilian aquaculture is crucial for developing effective control strategies against this fish pathogen. The present study conducted a genomic analysis of Brazilian <i>A. jandaei</i> strains with the obj...
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MDPI AG
2025-05-01
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| author | Marcela Laryssa Oliveira Duarte Diego Lucas Neres Rodrigues Gabryel Bernardo Vieira de Lima Juan Carlos Ariute Gisele Veneroni Gouveia João José de Simoni Gouveia Vasco Azevedo Bertram Brenig Eric Guédon Guilherme Campos Tavares Mateus Matiuzzi da Costa Ulisses de Pádua Pereira Flávia Figueira Aburjaile |
| author_facet | Marcela Laryssa Oliveira Duarte Diego Lucas Neres Rodrigues Gabryel Bernardo Vieira de Lima Juan Carlos Ariute Gisele Veneroni Gouveia João José de Simoni Gouveia Vasco Azevedo Bertram Brenig Eric Guédon Guilherme Campos Tavares Mateus Matiuzzi da Costa Ulisses de Pádua Pereira Flávia Figueira Aburjaile |
| author_sort | Marcela Laryssa Oliveira Duarte |
| collection | DOAJ |
| description | Understanding the genetic characteristics of <i>Aeromonas jandaei</i> in Brazilian aquaculture is crucial for developing effective control strategies against this fish pathogen. The present study conducted a genomic analysis of Brazilian <i>A. jandaei</i> strains with the objective of investigating their virulence potential and resistance profiles. Four Brazilian isolates were subjected to sequencing, and comparative genomic analyses were conducted in conjunction with 48 publicly available <i>A. jandaei</i> genomes. The methods employed included quality assessment, de novo assembly, annotation, and analyses of antimicrobial resistance and virulence factors. The results demonstrated the presence of fluoroquinolone resistance genes within the core genome. Notably, these antibiotics are not authorized for use in aquaculture in Brazil, suggesting that their resistance determinants may originate from other selective pressures or horizontal gene transfer unrelated to aquaculture practices. The analysis identified significant virulence mechanisms, including T2SS, T3SS, and notably T6SS (<i>vgrG3</i> gene), which was more prevalent in Brazilian isolates. Additionally, genes associated with motility, adhesion, and heavy metal resistance were identified. These findings highlight the enhanced adaptability of Brazilian <i>A. jandaei</i> strains and raise concerns about antimicrobial resistance in aquaculture, emphasizing the need for improved regulatory oversight and control strategies. |
| format | Article |
| id | doaj-art-267ac54a7b4a4129a681d0febd8bb3bb |
| institution | DOAJ |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-267ac54a7b4a4129a681d0febd8bb3bb2025-08-20T03:14:35ZengMDPI AGMicroorganisms2076-26072025-05-01135109410.3390/microorganisms13051094In Silico Characterization of Resistance and Virulence Genes in <i>Aeromonas jandaei</i> Strains Isolated from <i>Oreochromis niloticus</i> in BrazilMarcela Laryssa Oliveira Duarte0Diego Lucas Neres Rodrigues1Gabryel Bernardo Vieira de Lima2Juan Carlos Ariute3Gisele Veneroni Gouveia4João José de Simoni Gouveia5Vasco Azevedo6Bertram Brenig7Eric Guédon8Guilherme Campos Tavares9Mateus Matiuzzi da Costa10Ulisses de Pádua Pereira11Flávia Figueira Aburjaile12Preventive Veterinary Medicine Department, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, BrazilPreventive Veterinary Medicine Department, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, BrazilPreventive Veterinary Medicine Department, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, BrazilPreventive Veterinary Medicine Department, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, BrazilCampus of Agrarian Sciences, Federal University of the São Francisco Valley, Petrolina 56300-000, PE, BrazilCampus of Agrarian Sciences, Federal University of the São Francisco Valley, Petrolina 56300-000, PE, BrazilGenetics, Ecology and Evolution Department, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, BrazilInstitute of Veterinary Medicine, University of Göttingen, 37073 Göttingen, GermanySTLO, INRAE, Institut Agro, 35011 Rennes, FrancePreventive Veterinary Medicine Department, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, BrazilCampus of Agrarian Sciences, Federal University of the São Francisco Valley, Petrolina 56300-000, PE, BrazilPreventive Veterinary Medicine Department, State University of Londrina, Londrina 86057-970, PR, BrazilPreventive Veterinary Medicine Department, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, BrazilUnderstanding the genetic characteristics of <i>Aeromonas jandaei</i> in Brazilian aquaculture is crucial for developing effective control strategies against this fish pathogen. The present study conducted a genomic analysis of Brazilian <i>A. jandaei</i> strains with the objective of investigating their virulence potential and resistance profiles. Four Brazilian isolates were subjected to sequencing, and comparative genomic analyses were conducted in conjunction with 48 publicly available <i>A. jandaei</i> genomes. The methods employed included quality assessment, de novo assembly, annotation, and analyses of antimicrobial resistance and virulence factors. The results demonstrated the presence of fluoroquinolone resistance genes within the core genome. Notably, these antibiotics are not authorized for use in aquaculture in Brazil, suggesting that their resistance determinants may originate from other selective pressures or horizontal gene transfer unrelated to aquaculture practices. The analysis identified significant virulence mechanisms, including T2SS, T3SS, and notably T6SS (<i>vgrG3</i> gene), which was more prevalent in Brazilian isolates. Additionally, genes associated with motility, adhesion, and heavy metal resistance were identified. These findings highlight the enhanced adaptability of Brazilian <i>A. jandaei</i> strains and raise concerns about antimicrobial resistance in aquaculture, emphasizing the need for improved regulatory oversight and control strategies.https://www.mdpi.com/2076-2607/13/5/1094aquaculturebioinformaticsfish diseasespathogenomicsresistome |
| spellingShingle | Marcela Laryssa Oliveira Duarte Diego Lucas Neres Rodrigues Gabryel Bernardo Vieira de Lima Juan Carlos Ariute Gisele Veneroni Gouveia João José de Simoni Gouveia Vasco Azevedo Bertram Brenig Eric Guédon Guilherme Campos Tavares Mateus Matiuzzi da Costa Ulisses de Pádua Pereira Flávia Figueira Aburjaile In Silico Characterization of Resistance and Virulence Genes in <i>Aeromonas jandaei</i> Strains Isolated from <i>Oreochromis niloticus</i> in Brazil Microorganisms aquaculture bioinformatics fish diseases pathogenomics resistome |
| title | In Silico Characterization of Resistance and Virulence Genes in <i>Aeromonas jandaei</i> Strains Isolated from <i>Oreochromis niloticus</i> in Brazil |
| title_full | In Silico Characterization of Resistance and Virulence Genes in <i>Aeromonas jandaei</i> Strains Isolated from <i>Oreochromis niloticus</i> in Brazil |
| title_fullStr | In Silico Characterization of Resistance and Virulence Genes in <i>Aeromonas jandaei</i> Strains Isolated from <i>Oreochromis niloticus</i> in Brazil |
| title_full_unstemmed | In Silico Characterization of Resistance and Virulence Genes in <i>Aeromonas jandaei</i> Strains Isolated from <i>Oreochromis niloticus</i> in Brazil |
| title_short | In Silico Characterization of Resistance and Virulence Genes in <i>Aeromonas jandaei</i> Strains Isolated from <i>Oreochromis niloticus</i> in Brazil |
| title_sort | in silico characterization of resistance and virulence genes in i aeromonas jandaei i strains isolated from i oreochromis niloticus i in brazil |
| topic | aquaculture bioinformatics fish diseases pathogenomics resistome |
| url | https://www.mdpi.com/2076-2607/13/5/1094 |
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