Notch Signaling and PD-1/PD-L1 Interaction in Hepatocellular Carcinoma: Potentialities of Combined Therapies

Notch Signaling and PD-1/PD-L1 Interaction in Hepatocellular Carcinoma: Potentialities of Combined Therapies

Immunotherapy has shown significant improvement in the survival of patients with hepatocellular carcinoma (HCC) compared to TKIs as first-line treatment. Unfortunately, approximately 30% of HCC exhibits intrinsic resistance to ICIs, making new therapeutic combinations urgently needed. The dysregulat...

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Bibliographic Details
Main Authors: Annapaola Montagner, Andrea Arleo, Fabrizia Suzzi, Antonino B. D’Assoro, Fabio Piscaglia, Laura Gramantieri, Catia Giovannini
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomolecules
Subjects:
Notch
PD-1
PD-L1
hepatocellular carcinoma (HCC)
immunotherapy
combination therapy
Online Access:https://www.mdpi.com/2218-273X/14/12/1581
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