The association between albuminuria and arterial stiffness in a rural population from Northern China
ObjectiveTo investigate the association between albuminuria and arterial stiffness in a rural population from Northern China.MethodsUsing a stratified cluster multi-stage sampling method， residents over 30 years old from 13 villages in Yongnian County， Handan City， Hebei Province， China from October...
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Editorial Department of Journal of Clinical Nephrology
2025-04-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2025.04.005 |
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| author | Bao Shu-min Huang Wen Yang Jin-gang Liang Qiao-jing Liang Yuan-bo Wang Ning-li Zhang Guo-juan |
| author_facet | Bao Shu-min Huang Wen Yang Jin-gang Liang Qiao-jing Liang Yuan-bo Wang Ning-li Zhang Guo-juan |
| author_sort | Bao Shu-min |
| collection | DOAJ |
| description | ObjectiveTo investigate the association between albuminuria and arterial stiffness in a rural population from Northern China.MethodsUsing a stratified cluster multi-stage sampling method， residents over 30 years old from 13 villages in Yongnian County， Handan City， Hebei Province， China from October 1， 2006， to October 1， 2007 were selected. Finally， 3694 subjects were enrolled in the cross-sectional study. They were divided into the albuminuria group and non-albuminuria group according to the urinary albumin-to-creatinine ratio（ACR）. Brachial-ankle pulse wave velocity （baPWV） and other 19 factors were compared between the two groups. The subjects were then divided into four groups based on the baPWV values，and albuminuria and other 19 factors were compared among the four groups. Multivariate logistic regression analysis was used to evaluate the association between albuminuria and baPWV.ResultsBaPWV ［（1689.44 ± 430.60）cm/s <italic>vs</italic> （1556.49 ± 347.48）cm/s］， age ［（54.56 ± 10.49）years<italic> vs </italic>（50.96 ± 10.80）years］， female proportion （60.2% <italic>vs</italic> 53.4%）， systolic blood pressure ［（146.61 ± 24.10）mmHg<italic> vs </italic>（137.99 ± 20.98）mmHg， 1 mmHg=0.133 kPa］， diastolic blood pressure ［（80.28 ± 12.93）mmHg<italic> vs </italic>（77.37 ± 11.89）mmHg］， mean arterial pressure［（102.39 ± 15.07）mmHg<italic> vs </italic>（97.58 ± 13.61）mmHg］， pulse ［（66.34 ± 18.72）beats/min<italic> vs </italic>（60.62 ± 15.85）beats/min］， waist-to-hip ratio ［（0.91 ± 0.05）<italic>vs </italic>（0.90 ± 0.05）］， hypersensitivity C-reactive protein ［（1.05 ± 0.41）mg/L<italic> vs </italic>（0.82 ± 0.37）mg/L］， total cholesterol ［（4.80 ± 1.0）mmol/L<italic> vs </italic>（4.59 ± 0.94）mmol/L］， low-density lipoprotein ［（2.84 ± 0.66）mmol/L<italic> vs </italic>（2.70 ± 0.65）mmol/L］， and triacylglycerol ［（1.65 ± 1.26）mmol/L<italic> vs </italic>（1.50 ± 1.04）mmol/L］ were significantly higher in the albuminuria group than those of the non-albuminuria group （all <italic>P</italic><0.05）， while the estimated glomerular filtration rate （eGFR） ［90.95（81.37，99.54）mL·min<sup>-1</sup>·（1.73 m<sup>2</sup>）<sup>-1</sup><italic> vs</italic> 92.51（84.06，101.53）mL·min<sup>-1</sup>·（1.73 m<sup>2</sup>）<sup>-1</sup>］ was significantly lower in the albuminuria group （<italic>P</italic>=0.002）. More subjects in the albuminuria group suffered from hypertension （62.1% <italic>vs</italic> 47.0%， <italic>P</italic><0.001） or diabetes （10.7% <italic>vs</italic> 5.6%， <italic>P</italic><0.001）. The increase in baPWV was associated with the increase in ACR and the decrease in eGFR. Multivariate Logistic regression analysis showed that age， diabetes， blood creatinine， hypertension and baPWV were independent risk factors for elevated ACR， and the corresponding odds ratios （95% <italic>CI</italic>） were 1.018 （1.008-1.028）， 1.348 （1.094-1.660）， 1.548 （1.137-2.107）， 0.986 （0.978-0.004） and 1.0004 （1.000-1.001）， respectively.ConclusionIn the general population， there is a significant correlation between albuminuria and baPWV. |
| format | Article |
| id | doaj-art-267a565764b24adaaca22c8d79f1db68 |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2025-04-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-267a565764b24adaaca22c8d79f1db682025-08-20T03:49:02ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902025-04-012529730390384636The association between albuminuria and arterial stiffness in a rural population from Northern ChinaBao Shu-minHuang WenYang Jin-gangLiang Qiao-jingLiang Yuan-boWang Ning-liZhang Guo-juanObjectiveTo investigate the association between albuminuria and arterial stiffness in a rural population from Northern China.MethodsUsing a stratified cluster multi-stage sampling method， residents over 30 years old from 13 villages in Yongnian County， Handan City， Hebei Province， China from October 1， 2006， to October 1， 2007 were selected. Finally， 3694 subjects were enrolled in the cross-sectional study. They were divided into the albuminuria group and non-albuminuria group according to the urinary albumin-to-creatinine ratio（ACR）. Brachial-ankle pulse wave velocity （baPWV） and other 19 factors were compared between the two groups. The subjects were then divided into four groups based on the baPWV values，and albuminuria and other 19 factors were compared among the four groups. Multivariate logistic regression analysis was used to evaluate the association between albuminuria and baPWV.ResultsBaPWV ［（1689.44 ± 430.60）cm/s <italic>vs</italic> （1556.49 ± 347.48）cm/s］， age ［（54.56 ± 10.49）years<italic> vs </italic>（50.96 ± 10.80）years］， female proportion （60.2% <italic>vs</italic> 53.4%）， systolic blood pressure ［（146.61 ± 24.10）mmHg<italic> vs </italic>（137.99 ± 20.98）mmHg， 1 mmHg=0.133 kPa］， diastolic blood pressure ［（80.28 ± 12.93）mmHg<italic> vs </italic>（77.37 ± 11.89）mmHg］， mean arterial pressure［（102.39 ± 15.07）mmHg<italic> vs </italic>（97.58 ± 13.61）mmHg］， pulse ［（66.34 ± 18.72）beats/min<italic> vs </italic>（60.62 ± 15.85）beats/min］， waist-to-hip ratio ［（0.91 ± 0.05）<italic>vs </italic>（0.90 ± 0.05）］， hypersensitivity C-reactive protein ［（1.05 ± 0.41）mg/L<italic> vs </italic>（0.82 ± 0.37）mg/L］， total cholesterol ［（4.80 ± 1.0）mmol/L<italic> vs </italic>（4.59 ± 0.94）mmol/L］， low-density lipoprotein ［（2.84 ± 0.66）mmol/L<italic> vs </italic>（2.70 ± 0.65）mmol/L］， and triacylglycerol ［（1.65 ± 1.26）mmol/L<italic> vs </italic>（1.50 ± 1.04）mmol/L］ were significantly higher in the albuminuria group than those of the non-albuminuria group （all <italic>P</italic><0.05）， while the estimated glomerular filtration rate （eGFR） ［90.95（81.37，99.54）mL·min<sup>-1</sup>·（1.73 m<sup>2</sup>）<sup>-1</sup><italic> vs</italic> 92.51（84.06，101.53）mL·min<sup>-1</sup>·（1.73 m<sup>2</sup>）<sup>-1</sup>］ was significantly lower in the albuminuria group （<italic>P</italic>=0.002）. More subjects in the albuminuria group suffered from hypertension （62.1% <italic>vs</italic> 47.0%， <italic>P</italic><0.001） or diabetes （10.7% <italic>vs</italic> 5.6%， <italic>P</italic><0.001）. The increase in baPWV was associated with the increase in ACR and the decrease in eGFR. Multivariate Logistic regression analysis showed that age， diabetes， blood creatinine， hypertension and baPWV were independent risk factors for elevated ACR， and the corresponding odds ratios （95% <italic>CI</italic>） were 1.018 （1.008-1.028）， 1.348 （1.094-1.660）， 1.548 （1.137-2.107）， 0.986 （0.978-0.004） and 1.0004 （1.000-1.001）， respectively.ConclusionIn the general population， there is a significant correlation between albuminuria and baPWV.http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2025.04.005ProteinuriaArterial stiffnessBrachial-ankle pulse wave velocityChinaRural population |
| spellingShingle | Bao Shu-min Huang Wen Yang Jin-gang Liang Qiao-jing Liang Yuan-bo Wang Ning-li Zhang Guo-juan The association between albuminuria and arterial stiffness in a rural population from Northern China Linchuang shenzangbing zazhi Proteinuria Arterial stiffness Brachial-ankle pulse wave velocity China Rural population |
| title | The association between albuminuria and arterial stiffness in a rural population from Northern China |
| title_full | The association between albuminuria and arterial stiffness in a rural population from Northern China |
| title_fullStr | The association between albuminuria and arterial stiffness in a rural population from Northern China |
| title_full_unstemmed | The association between albuminuria and arterial stiffness in a rural population from Northern China |
| title_short | The association between albuminuria and arterial stiffness in a rural population from Northern China |
| title_sort | association between albuminuria and arterial stiffness in a rural population from northern china |
| topic | Proteinuria Arterial stiffness Brachial-ankle pulse wave velocity China Rural population |
| url | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2025.04.005 |
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